Windus David W, Ladenson Jack H, Merrins Cindy K, Seyoum Melles, Windus Debra, Morin Susan, Tewelde Beyene, Parvin Curtis A, Scott Mitchell G, Goldfeder Jason
Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
Clin Chem. 2007 Nov;53(11):1954-9. doi: 10.1373/clinchem.2007.095067.
When hemoglobin A1c (HbA1c) testing was made available to diabetic patients in the nation of Eritrea, the majority of values were markedly increased. As a result, a multidisciplinary clinical education program was instituted in Eritrea and the rate of HbA1c testing was increased to monitor progress.
In February 2003, a cooperative diabetes project was initiated in Eritrea to train diabetes educators, enhance physician education, create patient-teaching materials, and promote glucose monitoring. Two additional visits were made in 2003 and 2004. HbA1c values from January 2003 to November 2004 (n = 3606) were reviewed to assess diabetic control for the population and for a subset of individual patients (n = 350). A cohort of 209 diabetic persons were evaluated for demographics, treatment, and prevalence of complications.
The cohort of 209 patients was 34% female and had a mean (SD) age of 50.5 (15.5) years and diabetes duration of 8.6 (6.3) years. Prevalence of hypertension was 37% and proteinuria 6%. For diabetes treatment, 59% received insulin therapy, 35% received oral agents, and 6% received nonpharmacologic treatment. HbA1c values improved significantly between the 1st 6 months of 2003 (median 10.9%) and the last 6 months of 2004 (median 8.5%; P <0.001). Individual patients in whom 2 HbA1c values were measured > or =3 months apart showed a significant mean decrease of 0.5% (P <0.001).
Our experience suggests that the combination of sustainable upgraded laboratory services and training in clinical management leads to sustainable improvement in diabetes care in developing countries.
当厄立特里亚国向糖尿病患者提供糖化血红蛋白(HbA1c)检测时,大多数检测值显著升高。因此,厄立特里亚实施了一项多学科临床教育计划,并提高了HbA1c检测率以监测进展情况。
2003年2月,在厄立特里亚启动了一个合作糖尿病项目,以培训糖尿病教育工作者、加强医生教育、制作患者教育材料并推广血糖监测。2003年和2004年又进行了两次访问。对2003年1月至2004年11月期间的HbA1c值(n = 3606)进行了回顾,以评估总体人群以及一部分个体患者(n = 350)的糖尿病控制情况。对209名糖尿病患者组成的队列进行了人口统计学、治疗情况及并发症患病率的评估。
209名患者的队列中女性占34%,平均(标准差)年龄为50.5(15.5)岁,糖尿病病程为8.6(6.3)年。高血压患病率为37%,蛋白尿患病率为6%。对于糖尿病治疗,59%的患者接受胰岛素治疗,35%接受口服药物治疗,6%接受非药物治疗。2003年的前6个月(中位数为10.9%)至2004年的后6个月(中位数为8.5%;P <0.001),HbA1c值有显著改善。相隔≥3个月测量了两次HbA1c值的个体患者,平均显著下降了0.5%(P <0.001)。
我们的经验表明,可持续升级的实验室服务与临床管理培训相结合,可使发展中国家的糖尿病护理得到可持续改善。