Yilmaz M, Okan V, Pehlivan M, Ozkur A, Pehlivan Y, Buyukhatipoglu H, Sari I
Department of Hematology, School of Medicine, Gaziantep University, Gaziantep, Turkey.
Platelets. 2007 Nov;18(7):540-2. doi: 10.1080/09537100701321268.
Immune thrombocytopenia is commonly seen in patients with lymphoproliferative disorders, but is rare in patients with multiple myeloma. POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, monoclonal protein, skin changes) is defined by the presence of a peripheral neuropathy, a monoclonal plasma cell disorder, and at least one of the following: endocrinopathy, skin changes, osteosclerotic myeloma, Castleman's disease, organomegaly, edema, or papilledema. In this paper, we present a patient with immune thrombocytopenic purpura (ITP) who developed POEMS syndrome during the clinical course of his ITP, and report on the early appearance of an isolated paraneoplastic symptom before the other diagnostic components of POEMS syndrome had developed. To our knowledge, this is the first description of coexistent ITP and POEMS syndrome in the literature.
免疫性血小板减少症在淋巴增殖性疾病患者中很常见，但在多发性骨髓瘤患者中很少见。POEMS综合征（多发性神经病变、器官肿大、内分泌病变、单克隆蛋白、皮肤改变）的定义为存在周围神经病变、单克隆浆细胞疾病，以及以下至少一项：内分泌病变、皮肤改变、骨硬化性骨髓瘤、Castleman病、器官肿大、水肿或视乳头水肿。在本文中，我们报告了一名患有免疫性血小板减少性紫癜（ITP）的患者，该患者在ITP临床过程中发展为POEMS综合征，并报告了在POEMS综合征的其他诊断成分出现之前，一种孤立的副肿瘤症状的早期出现。据我们所知，这是文献中首次对ITP与POEMS综合征共存的描述。
