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阻塞性唾液腺疾病的现代管理

Modern management of obstructive salivary diseases.

作者信息

Capaccio P, Torretta S, Ottavian F, Sambataro G, Pignataro L

机构信息

Department of Otorhinolaryngological and Ophthalmological Sciences, University of Milan, Fondazione IRCCS Maggiore Policlinico Mangiagalli and Regina Elena Hospital, Milan, Italy.

出版信息

Acta Otorhinolaryngol Ital. 2007 Aug;27(4):161-72.

Abstract

Over the last fifteen years, increasing public demand for minimally-invasive surgery and recent technological advances have led to the development of a number of conservative options for the therapeutic management of obstructive salivary disorders such as calculi and duct stenosis. These include extracorporeal shock-wave lithotripsy, sialoendoscopy, laser intra-corporeal lithotripsy, interventional radiology, the video-assisted conservative surgical removal of parotid and sub-mandibular calculi and botulinum toxin therapy. Each of these techniques may be used as a single therapeutic modality or in combination with one or more of the above-mentioned options, usually in day case or one-day case under local or general anaesthesia. The multi-modal approach is completely successful in about 80% of patients and reduces the need for gland removal in 3%, thus justifying the combination of, albeit, time-consuming and relatively expensive techniques as part of the modern and functional management of salivary calculi. With regard to the management of salivary duct anomalies, such as strictures and kinkings, interventional radiology with fluoroscopically controlled balloon ductoplasty seems to be the most suitable technique despite the use of radiation. Operative sialoendoscopy alone is the best therapeutic option for all mobile intra-luminal causes of obstruction, such as microliths, mucous plugs or foreign bodies, or for the local treatment of inflammatory conditions such as recurrent chronic parotitis or autoimmune salivary disorders. Finally, in the case of failure of one of the above techniques and regardless of the cause of obstruction, botulinum toxin injection into the parenchyma of the salivary glands using colour Doppler ultrasonographic monitoring should be considered before deciding on surgical gland removal.

摘要

在过去的十五年里,公众对微创手术的需求不断增加,以及最近的技术进步,促使人们开发出了多种保守治疗方法,用于治疗诸如结石和导管狭窄等阻塞性唾液腺疾病。这些方法包括体外冲击波碎石术、唾液腺内镜检查、体内激光碎石术、介入放射学、视频辅助保守手术切除腮腺和下颌下腺结石以及肉毒杆菌毒素治疗。这些技术中的每一种都可以作为单一的治疗方式使用,也可以与上述一种或多种方法联合使用,通常在局部或全身麻醉下的日间手术或一日手术中进行。多模式方法在大约80%的患者中完全成功,并将腺体切除的需求降低了3%,因此,尽管这些技术耗时且相对昂贵,但作为唾液腺结石现代功能性管理的一部分,将它们联合使用是合理的。关于唾液腺导管异常(如狭窄和扭曲)的管理,尽管使用了辐射,但在荧光透视控制下进行球囊导管成形术的介入放射学似乎是最合适的技术。单独的手术唾液腺内镜检查是所有腔内活动性阻塞原因(如微结石、粘液栓或异物)或局部治疗炎症性疾病(如复发性慢性腮腺炎或自身免疫性唾液腺疾病)的最佳治疗选择。最后,如果上述技术之一失败,且无论阻塞原因如何,在决定手术切除腺体之前,应考虑在彩色多普勒超声监测下向唾液腺实质内注射肉毒杆菌毒素。

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