Malvy D, Ezzedine K, Lançon F, Halioua B, Rezvani A, Bertrais S, Chanzy B, Malkin J-E, Morand P, De Labareyre C, Hercberg S, El Hasnaoui A
Département des Maladies Infectieuses et Tropicales, Centre Hospitalier Universitaire de Bordeaux and Centre René-Labusquière, Université de Bordeaux II, Bordeaux, France.
J Eur Acad Dermatol Venereol. 2007 Nov;21(10):1398-403. doi: 10.1111/j.1468-3083.2007.02302.x.
Prevalence of clinically manifest orofacial herpes in the general population is poorly characterized. Objectives To establish the lifetime prevalence of clinically manifest orofacial herpes and its relationship with herpes simplex virus (HSV) serotype in the French general population.
PATIENTS/METHODS: Subjects (N = 2796) were serotyped for HSV1 and HSV2 and provided data on herpetic symptoms by questionnaire. Subjects reporting at least one episode of orobuccal ulcerative mucosal lesions were classified as clinically manifest orofacial herpes.
Lifetime prevalence of clinically manifest orofacial herpes was 38.3% (42.1% in women, 32.4% in men). Prevalence in subjects seropositive for HSV1 was 50.3%. This prevalence rate was independent of HSV2 serotype. Prevalence in subjects infected with HSV2 alone was similar to that in subjects seronegative for HSV.
Lack of case ascertainment limits precision of the data.
Clinically manifest orofacial herpes was reported in one third of the sample, principally associated with HSV1 infection. HSV2 infection did not produce orofacial lesions nor influence clinical manifestations of HSV1 infection.
普通人群中临床显性口腔面部疱疹的患病率特征尚不明确。目的：确定法国普通人群中临床显性口腔面部疱疹的终生患病率及其与单纯疱疹病毒（HSV）血清型的关系。
患者/方法：对2796名受试者进行HSV1和HSV2血清分型，并通过问卷调查收集疱疹症状的数据。报告至少有一次口腔颊部溃疡性黏膜病变发作的受试者被归类为临床显性口腔面部疱疹。
临床显性口腔面部疱疹的终生患病率为38.3%（女性为42.1%，男性为32.4%）。HSV1血清阳性受试者的患病率为50.3%。该患病率与HSV2血清型无关。仅感染HSV2的受试者的患病率与HSV血清阴性受试者的患病率相似。
病例确诊不足限制了数据的准确性。
在三分之一的样本中报告了临床显性口腔面部疱疹，主要与HSV1感染有关。HSV2感染未产生口腔面部病变，也不影响HSV1感染的临床表现。
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