Zimmerman B, Gold M
Adverse Reaction Clinic, Toronto, Canada.
Pediatrician. 1991;18(4):312-6.
Chronic sinusitis has been suggested to play a causal role in creating recalcitrant asthma. However, this hypothesis has never been confirmed in a blind placebo-controlled study. Several studies have documented an association between abnormal sinus X-rays and asthma in 30-70% of patients, depending on criteria chosen for evaluation of the radiologic changes. Asthma is associated with inflammation in the lower airways, and the same inflammation might involve the sinuses in a parallel fashion. It is now felt that early therapy of this inflammation can modify the course of asthma resulting in its amelioration. Conversely, delay in institution of this therapy might result in the inflammation entrenching airway reactivity. It must be clearly proven in a controlled fashion that antibiotic or other therapy of sinusitis will improve the course of asthma since such therapy could delay the aggressive management of inflammation.
慢性鼻窦炎被认为在难治性哮喘的发生中起因果作用。然而，这一假设从未在一项盲法安慰剂对照研究中得到证实。多项研究记录了30%至70%的患者鼻窦X线异常与哮喘之间的关联，具体比例取决于评估放射学改变所选用的标准。哮喘与下呼吸道炎症相关，同样的炎症可能以类似的方式累及鼻窦。现在人们认为，对这种炎症进行早期治疗可以改变哮喘的病程，从而使其得到改善。相反，延迟进行这种治疗可能会导致炎症使气道反应性更加顽固。必须通过对照研究明确证明，鼻窦炎的抗生素治疗或其他治疗能够改善哮喘的病程，因为这种治疗可能会延迟对炎症的积极处理。
