Waters Michael, Stasiewicz Stanley, Merrick B Alex, Tomer Kenneth, Bushel Pierre, Paules Richard, Stegman Nancy, Nehls Gerald, Yost Kenneth J, Johnson C Harris, Gustafson Scott F, Xirasagar Sandhya, Xiao Nianqing, Huang Cheng-Cheng, Boyer Paul, Chan Denny D, Pan Qinyan, Gong Hui, Taylor John, Choi Danielle, Rashid Asif, Ahmed Ayazaddin, Howle Reese, Selkirk James, Tennant Raymond, Fostel Jennifer
NIEHS, National Center for Toxicogenomics, PO Box 12233, Research Triangle Park, NC 27709, USA.
Nucleic Acids Res. 2008 Jan;36(Database issue):D892-900. doi: 10.1093/nar/gkm755. Epub 2007 Oct 25.
CEBS (Chemical Effects in Biological Systems) is an integrated public repository for toxicogenomics data, including the study design and timeline, clinical chemistry and histopathology findings and microarray and proteomics data. CEBS contains data derived from studies of chemicals and of genetic alterations, and is compatible with clinical and environmental studies. CEBS is designed to permit the user to query the data using the study conditions, the subject responses and then, having identified an appropriate set of subjects, to move to the microarray module of CEBS to carry out gene signature and pathway analysis. Scope of CEBS: CEBS currently holds 22 studies of rats, four studies of mice and one study of Caenorhabditis elegans. CEBS can also accommodate data from studies of human subjects. Toxicogenomics studies currently in CEBS comprise over 4000 microarray hybridizations, and 75 2D gel images annotated with protein identification performed by MALDI and MS/MS. CEBS contains raw microarray data collected in accordance with MIAME guidelines and provides tools for data selection, pre-processing and analysis resulting in annotated lists of genes of interest. Additionally, clinical chemistry and histopathology findings from over 1500 animals are included in CEBS. CEBS/BID: The BID (Biomedical Investigation Database) is another component of the CEBS system. BID is a relational database used to load and curate study data prior to export to CEBS, in addition to capturing and displaying novel data types such as PCR data, or additional fields of interest, including those defined by the HESI Toxicogenomics Committee (in preparation). BID has been shared with Health Canada and the US Environmental Protection Agency. CEBS is available at http://cebs.niehs.nih.gov. BID can be accessed via the user interface from https://dir-apps.niehs.nih.gov/arc/. Requests for a copy of BID and for depositing data into CEBS or BID are available at http://www.niehs.nih.gov/cebs-df/.
生物系统中的化学效应（CEBS）是一个用于存储毒理基因组学数据的综合性公共数据库，包括研究设计和时间表、临床化学和组织病理学发现以及微阵列和蛋白质组学数据。CEBS包含来自化学物质研究和基因改变研究的数据，并且与临床和环境研究兼容。CEBS旨在允许用户根据研究条件、受试者反应查询数据，然后在确定了一组合适的受试者后，进入CEBS的微阵列模块进行基因特征和通路分析。CEBS的范围：CEBS目前拥有22项大鼠研究、4项小鼠研究和1项秀丽隐杆线虫研究。CEBS还可以容纳来自人类受试者研究的数据。目前CEBS中的毒理基因组学研究包括超过4000次微阵列杂交，以及75张二维凝胶图像，这些图像标注了通过基质辅助激光解吸电离飞行时间质谱（MALDI）和串联质谱（MS/MS）进行的蛋白质鉴定。CEBS包含根据MIAME指南收集的原始微阵列数据，并提供数据选择、预处理和分析工具，生成感兴趣基因的注释列表。此外，CEBS还包括来自1500多只动物的临床化学和组织病理学发现。CEBS/BID：BID（生物医学研究数据库）是CEBS系统的另一个组成部分。BID是一个关系数据库，用于在导出到CEBS之前加载和整理研究数据，此外还用于捕获和显示新的数据类型，如PCR数据，或其他感兴趣的字段，包括由HESI毒理基因组学委员会（正在编写）定义的字段。BID已与加拿大卫生部和美国环境保护局共享。可通过http://cebs.niehs.nih.gov访问CEBS。可通过用户界面从https://dir-apps.niehs.nih.gov/arc/访问BID。有关获取BID副本以及将数据存入CEBS或BID的请求，请访问http://www.niehs.nih.gov/cebs-df/。
Zotero 插件
