First synthesis of 3-acetyl-2-aminothiophenes using the Gewald reaction.
作者信息
Eller Gernot A, Holzer Wolfgang
机构信息
Department of Drug Synthesis, Faculty of Life Sciences, University of Vienna, Austria.
出版信息
Molecules. 2006 May 16;11(5):371-6. doi: 10.3390/11050371.
Abstract
Novel 3-acetyl-2-aminothiophenes were prepared from cyanoacetone and 1,4-dithianyl-2,5-diols using a modified Gewald reaction. The syntheses of the corresponding acetamides, as well as that of 3-acetyl-2-amino-5-nitrothiophene - an interesting building-block for thiophene azo dyes - are reported. Detailed spectroscopic investigations ((1)H-NMR, (13)C-NMR, MS, IR) of the obtained compounds are presented.
摘要
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First synthesis of 3-acetyl-2-aminothiophenes using the Gewald reaction.
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