CuI/TMEDA 催化 2-溴代炔基苯与 Na2S 的环化反应：苯并[b]噻吩的合成。
CuI/TMEDA-catalyzed annulation of 2-bromo alkynylbenzenes with Na2S: synthesis of benzo[b]thiophenes.
机构信息
College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou 325035, China.
出版信息
J Org Chem. 2011 Sep 16;76(18):7546-50. doi: 10.1021/jo201081v. Epub 2011 Aug 17.
PMID:21812478
Abstract
A copper-catalyzed thiolation annulation reaction of 2-bromo alkynylbenzenes with sodium sulfide has been developed. In the presence of CuI and TMEDA, a variety of 2-substituted benzo[b]thiophenes were readily prepared in moderate to good yields by the reaction of 2-bromo alkynylbenzenes and Na(2)S·9H(2)O.
摘要
发展了一种铜催化的 2-溴代炔基苯与硫化钠的硫代环化反应。在 CuI 和 TMEDA 的存在下，2-溴代炔基苯与 Na(2)S·9H(2)O 的反应以中等至良好的产率得到了多种 2-取代的苯并[b]噻吩。
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