Choussy Olivier, Babin Emmanuel, Temam Stéphane, Cosmidis Alain, Vedrine Pierre-Olivier, De Raucourt Dominique, Sarini Jérôme, Bessede Jean-Pierre, Lienhardt Pierre-Yves, Dehesdin Danièle
ENT Department, Rouen University Hospital, 1, rue de Germont, 76031, Rouen, France.
Eur Arch Otorhinolaryngol. 2008 Jan;265(1):35-41. doi: 10.1007/s00405-007-0503-x. Epub 2007 Oct 26.
Squamous cell carcinoma of the nasal columella (SCCNC) is a rare disease. We aimed to define a strategy for the diagnosis and management of nasal columella squamous cell carcinoma. Medical records of 66 patients presenting with columella squamous cell carcinoma in nine French hospitals, from 1980 to 2003, were evaluated to determine the clinical characteristics and current treatment of the disease. Mean age was 69 years. The sex ratio was one female for three males. Majority of the lesions were T1 N0 according to the classification international union against cancer. Patients underwent one of the three treatments: surgery alone for the T1 lesions, radiotherapy for tumors of T2-T3 and combined (surgery and radiotherapy) for T4 lesions. The 5-year Kaplan-Meier survival test was 39% and no difference was found between the therapeutic groups. Thirty-five (53%) tumor recurrences were observed with a median time of 43 months. As regards TNM classification and treatment, no significant difference between the two groups disease free/recurrence was found. Prognosis of early lesions was considered better than the advanced lesions. SCCNC is difficult to manage and has a poor prognosis. No therapeutic solution has yet been confirmed in the treatment of this pathology.
鼻小柱鳞状细胞癌(SCCNC)是一种罕见疾病。我们旨在确定一种鼻小柱鳞状细胞癌的诊断和管理策略。对1980年至2003年期间在法国九家医院就诊的66例鼻小柱鳞状细胞癌患者的病历进行评估,以确定该疾病的临床特征和当前治疗方法。平均年龄为69岁。男女比例为1名女性对应3名男性。根据国际抗癌联盟的分类,大多数病变为T1 N0。患者接受了以下三种治疗方法之一:T1病变仅行手术治疗,T2 - T3肿瘤行放射治疗,T4病变行联合治疗(手术和放疗)。5年的Kaplan - Meier生存率为39%,各治疗组之间未发现差异。观察到35例(53%)肿瘤复发,中位复发时间为43个月。关于TNM分类和治疗,在无病/复发两组之间未发现显著差异。早期病变的预后被认为优于晚期病变。鼻小柱鳞状细胞癌难以管理且预后较差。在这种病理的治疗中,尚未证实有有效的治疗方案。