Patel P, Tiwari R, Karim A B, Nauta J J, Snow G B
Department of Otolaryngology, Free University Hospital, Amsterdam, The Netherlands.
J Laryngol Otol. 1992 Apr;106(4):332-6. doi: 10.1017/s0022215100119425.
We reviewed 30 patients with squamous cell carcinoma of the nasal vestibule to present our experience of their management and to evaluate the prognostic factors that may influence their outcome. For T1 lesions radiotherapy remains the treatment of choice, because of the superior cosmetic result. Fifteen (68 per cent) out of 22 patients with T2 lesions were treated with primary radiotherapy. Surgery however, was eventually required in 16 (72 per cent) out of 22 patients, either as a primary treatment (seven patients) or as salvage surgery (nine patients). For the larger T3 lesions the treatment of choice is surgery followed by post-operative radiotherapy where appropriate. Regional nodal metastases at the time of presentation were a significant indicator of local and regional recurrence and of prognosis. The cause specific five-year survival for patients with an uninvolved neck (22 patients) was 100 per cent compared with 38 per cent for patients with nodal metastases at presentation (eight patients). Elective treatment for uninvolved regional nodes is not considered necessary.
我们回顾了30例鼻前庭鳞状细胞癌患者的情况，以介绍我们的治疗经验，并评估可能影响其预后的因素。对于T1期病变，由于美容效果更佳，放疗仍是首选治疗方法。22例T2期病变患者中有15例（68%）接受了原发性放疗。然而，22例患者中有16例（72%）最终需要手术，其中7例作为原发性治疗，9例作为挽救性手术。对于较大的T3期病变，首选治疗方法是手术，必要时术后进行放疗。就诊时区域淋巴结转移是局部和区域复发以及预后的重要指标。颈部未受累患者（22例）的特定病因五年生存率为100%，而就诊时伴有淋巴结转移的患者（8例）为38%。对于未受累的区域淋巴结，不考虑进行选择性治疗。
