Liu Y X, Feng Q, Zou R J
Laboratory of Reproductive Biology, Chinese Academy of Sciences, Beijing.
Sheng Li Xue Bao. 1991 Oct;43(5):472-9.
Changes of plasminogen activator (PA) and its inhibitor (PAI-1) activity and antigen have been investigated during PMSG/hCG induced ovulation in rhesus monkeys. It has been demonstrated that the ovarian tissue type PA (tPA) activity, which reaches maximum prior to ovulation and declines thereafter, is closely related to follicular rupture; significant increases in urokinase type PA (uPA) only occurs in granulosa cells after ovulation. Since the secretory activity of ovarian PAI-1 reaches its peak level 12-24 h earlier than tPA the rapid decrease in PAI-1 activity in the approach of ovulation is correlated with the elevation of tPA activity. It is, therefore, suggested that a counterbalance of tPA and PAI-1 activity within the ovary may play an important role in the ovulation mechanism, whereas uPA may be involved in the regulation of corpus luteum formation.
在恒河猴中，已对孕马血清促性腺激素/人绒毛膜促性腺激素（PMSG/hCG）诱导排卵过程中纤溶酶原激活物（PA）及其抑制剂（PAI-1）的活性和抗原变化进行了研究。结果表明，卵巢组织型PA（tPA）活性在排卵前达到最高水平，之后下降，这与卵泡破裂密切相关；仅在排卵后，颗粒细胞中的尿激酶型PA（uPA）才会显著增加。由于卵巢PAI-1的分泌活性比tPA提前12 - 24小时达到峰值水平，因此排卵临近时PAI-1活性的快速下降与tPA活性的升高相关。因此，提示卵巢内tPA和PAI-1活性的平衡可能在排卵机制中起重要作用，而uPA可能参与黄体形成的调节。
