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[正常条件下及实验性心脏过敏性病变时兔心脏线粒体的半衰期]

[Half-life of rabbit heart mitochondria under normal conditions and in experimental allergic lesions of the heart].

作者信息

Grozdova M D, Starostina L K, Sharlova I L

出版信息

Biull Eksp Biol Med. 1975 May;79(5):86-9.

PMID:179638
Abstract

Half-life of mitochondrial proteins and cytochrome C of rabbit myocardium was determined with glycine-I-C14 and H3-5-aminolevulinic acid, respectively, as precursors. Half-life of mitochondrial proteins calculated from the curve of the gradual radioactivity decline was 14.4 days, and that of cytochrome C--11.8 days; reutilization of glycine-C14 in plastic metabolism did not exceed 20%. No difference from control was noticed in rabbits with an experimental allergic heart damage.

摘要

分别以甘氨酸-I-C14和H3-5-氨基乙酰丙酸作为前体,测定了兔心肌线粒体蛋白和细胞色素C的半衰期。根据放射性逐渐下降曲线计算出的线粒体蛋白半衰期为14.4天,细胞色素C的半衰期为11.8天;甘氨酸-C14在蛋白质代谢中的再利用率不超过20%。在实验性过敏性心脏损伤的兔子中未发现与对照组有差异。

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