来自桥本脑病患者的抗甲状腺过氧化物酶抗体与小脑星形胶质细胞结合。
Anti-thyroperoxidase antibodies from patients with Hashimoto's encephalopathy bind to cerebellar astrocytes.
作者信息
Blanchin Stéphanie, Coffin Christine, Viader Fausto, Ruf Jean, Carayon Pierre, Potier Francette, Portier Estelle, Comby Elisabeth, Allouche Stéphane, Ollivier Yann, Reznik Yves, Ballet Jean Jacques
机构信息
Laboratoire d'Immunologie et d'Immunopathologie, UPRES-EA 2128, CHU Clémenceau, 14033 Caen cedex, France.
出版信息
J Neuroimmunol. 2007 Dec;192(1-2):13-20. doi: 10.1016/j.jneuroim.2007.08.012. Epub 2007 Oct 26.
A cohort of 10 Hashimoto's encephalopathy (HE) patients, 33 patients with unrelated neurological symptoms, 12 Hashimoto's thyroiditis patients and 4 healthy adult donors was studied to explore the neurological targets of anti-thyroperoxidase (TPO) autoantibodies (aAb) in HE. High levels of anti-TPO aAb were only detected in HE group's cerebrospinal fluids. In immunofluorescence assays on monkey brain cerebellum sections, both HE patients' sera and anti-TPO monoclonal antibodies (mAb) were able to bind cerebellar cells expressing glial fibrillary acid protein. Normal human astrocytes from primary cultures also reacted with anti-TPO mAb. Specific astrocyte binding of anti-TPO aAb suggests a role of these aAb in the HE pathogenesis.
研究了一组10例桥本脑病（HE）患者、33例有无关神经症状的患者、12例桥本甲状腺炎患者和4名健康成年供者，以探索HE中抗甲状腺过氧化物酶（TPO）自身抗体（aAb）的神经学靶点。仅在HE组的脑脊液中检测到高水平的抗TPO aAb。在猴脑小脑切片的免疫荧光试验中，HE患者的血清和抗TPO单克隆抗体（mAb）均能与表达胶质纤维酸性蛋白的小脑细胞结合。原代培养的正常人星形胶质细胞也与抗TPO mAb发生反应。抗TPO aAb与星形胶质细胞的特异性结合表明这些aAb在HE发病机制中起作用。
Zotero 插件