Novel imidazo[1,2-a]pyrazine derivatives as potent reversible inhibitors of the gastric H+/K+-ATPase.

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作者信息

Zimmermann Peter Jan, Brehm Christof, Buhr Wilm, Palmer Andreas Marc, Volz Jürgen, Simon Wolfgang-Alexander

机构信息

Nycomed GmbH, Byk-Gulden-Str. 2, D-78467 Konstanz, Germany.

出版信息

Bioorg Med Chem. 2008 Jan 1;16(1):536-41. doi: 10.1016/j.bmc.2007.09.009. Epub 2007 Sep 12.

DOI:10.1016/j.bmc.2007.09.009

PMID:17964794

Abstract

A series of novel 6-substituted imidazo[1,2-a]pyrazines were synthesized via palladium catalyzed amino- or alkoxycarbonylation as key step. The anti-secretory activity of these compounds has been assessed in a binding assay against H(+)/K(+)-ATPase from hog gastric mucosa. Some of the compounds proved to be potent inhibitors of the gastric acid pump.

摘要

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