Goldberg Gabrielle L, Zakrzewski Johannes L, Perales Miguel A, van den Brink Marcel R M
Department of Immunology, Laboratory of the Immunology of Bone Marrow Transplantation, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.
Semin Immunol. 2007 Oct;19(5):289-96. doi: 10.1016/j.smim.2007.08.001. Epub 2007 Oct 26.
Strategies to enhance T cell recovery are of increasing clinical importance to overcome long lasting T cell deficiencies, which occur in association with infections, autoimmunity and chemo/radiotherapy as well as aging of the immune system. In this review we discuss those strategies that are close to or in the clinic. Interleukin-7, sex steroid modulation, keratinocyte growth factor, growth hormone and cellular therapies using ex vivo generated T-cell precursors are currently being tested in recipients of a hematopoietic stem cell transplantation and patients with malignancies or HIV/AIDS.
增强T细胞恢复的策略对于克服与感染、自身免疫、化疗/放疗以及免疫系统衰老相关的长期T细胞缺陷具有越来越重要的临床意义。在本综述中,我们讨论了那些已接近临床应用或正在临床应用的策略。白细胞介素-7、性类固醇调节、角质形成细胞生长因子、生长激素以及使用体外生成的T细胞前体的细胞疗法目前正在造血干细胞移植受者以及患有恶性肿瘤或艾滋病毒/艾滋病的患者中进行测试。