白细胞介素-7 与免疫衰老。
Interleukin-7 and Immunosenescence.
机构信息
Panorama Research Institute, 1230 Bordeaux Drive, Sunnyvale, CA 94089, USA.
出版信息
J Immunol Res. 2017;2017:4807853. doi: 10.1155/2017/4807853. Epub 2017 Apr 6.
Abstract
The age of an individual is an important, independent risk factor for many of the most common diseases afflicting modern societies. Interleukin-7 (IL-7) plays a central, critical role in the homeostasis of the immune system. Recent studies support a critical role for IL-7 in the maintenance of a vigorous healthspan. We describe the role of IL-7 and its receptor in immunosenescence, the aging of the immune system. An understanding of the role that IL-7 plays in aging may permit parsimonious preventative or therapeutic solutions for diverse conditions. Perhaps IL-7 might be used to "tune" the immune system to optimize human healthspan and longevity.
摘要
个体的年龄是现代社会中许多最常见疾病的一个重要、独立的风险因素。白细胞介素-7（IL-7）在免疫系统的动态平衡中起着核心、关键的作用。最近的研究支持 IL-7 在维持健康的寿命方面起着关键作用。我们描述了 IL-7 及其受体在免疫衰老（免疫系统的衰老）中的作用。了解 IL-7 在衰老中的作用可能为各种疾病提供简洁的预防或治疗方法。也许可以使用 IL-7 来“调整”免疫系统，以优化人类的健康寿命和长寿。
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