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病原体信息学的一项新资产——肠道病原体资源整合中心(ERIC),这是美国国立过敏与传染病研究所(NIAID)设立的一个用于生物防御和新发/再发传染病的生物信息学资源中心。

A new asset for pathogen informatics--the Enteropathogen Resource Integration Center (ERIC), an NIAID Bioinformatics Resource Center for Biodefense and Emerging/Re-emerging Infectious Disease.

作者信息

Greene John M, Plunkett Guy, Burland Valerie, Glasner Jeremy, Cabot Eric, Anderson Brad, Neeno-Eckwall Eric, Qiu Yu, Mau Bob, Rusch Michael, Liss Paul, Hampton Thomas, Pot David, Shaker Matthew, Shaull Lorie, Shetty Panna, Shi Chuan, Whitmore Jon, Wong Mary, Zaremba Sam, Blattner Frederick R, Perna Nicole T

机构信息

Health Research Systems, SRA International, Inc., Rockville, MD, USA.

出版信息

Adv Exp Med Biol. 2007;603:28-42. doi: 10.1007/978-0-387-72124-8_4.

Abstract

ERIC (Enteropathogen Resource Information Center) is one of the National Institute of Allergy and Infectious Diseases (NIAID) Bioinformatics Resource Centers for Biodefense and Emerging/Re-emerging Infectious Disease. ERIC serves as a comprehensive information resource for five related pathogens: Yersinia enterocolitica, Yersinia pestis, diarrheagenic E. coli, Shigella spp., and Salmonella spp. ERIC integrates genomics, proteomics, biochemical and microbiological information to facilitate the interpretation and understanding of ERIC pathogens and select related non-pathogens for the advancement of diagnostics, therapeutics, and vaccines. ERIC (www.ericbrc.org) is evolving to provide state-of-the-art analysis tools and data types, such as genome sequencing, comparative genomics, genome polymorphisms, gene expression, proteomics, and pathways as well as expertly curated community genome annotation. Genome sequence and genome annotation data and a variety of analysis and tools for eight strains of Yersinia enterocolitica and Yersinia pestis pathogens (Yersinia pestis biovars Mediaevalis KIM, Mediaevalis 91001, Orientalis CO92, Orientalis IP275, Antiqua Angola, Antiqua Antiqua, Antiqua Nepal516, and Yersinia enterocolitica 8081) and two strains of Yersinia pseudotuberculosis (Yersinia pseudotuberculosis IP32953 and IP31758) are currently available through the ERIC portal. ERIC seeks to maintain a strong collaboration with the scientific community so that we can continue to identify and incorporate the latest research data, tools, and training to best meet the current and future needs of the enteropathogen research community. All tools and data developed under this NIAID contract will be freely available. Please contact info@ericbrc.org for more information.

摘要

肠道病原体资源信息中心(ERIC)是美国国立过敏与传染病研究所(NIAID)设立的生物信息学资源中心之一,致力于生物防御以及新发/再发传染病研究。ERIC为五种相关病原体提供全面的信息资源,这五种病原体分别是:小肠结肠炎耶尔森菌、鼠疫耶尔森菌、致泻性大肠杆菌、志贺菌属以及沙门菌属。ERIC整合了基因组学、蛋白质组学、生物化学和微生物学信息,以促进对ERIC病原体的解读和理解,并挑选相关的非病原体,推动诊断、治疗和疫苗方面的进展。ERIC(www.ericbrc.org)正在不断发展,以提供最先进的分析工具和数据类型,如基因组测序、比较基因组学、基因组多态性、基因表达、蛋白质组学和代谢途径,以及经过专业策划的社区基因组注释。目前可通过ERIC门户网站获取小肠结肠炎耶尔森菌和鼠疫耶尔森菌病原体(鼠疫耶尔森菌中世纪生物变种KIM、中世纪生物变种91001、东方生物变种CO92、东方生物变种IP275、古典型安哥拉、古典型古典型、古典型尼泊尔516以及小肠结肠炎耶尔森菌8081)的八个菌株,以及假结核耶尔森菌的两个菌株(假结核耶尔森菌IP32953和IP31758)的基因组序列、基因组注释数据以及各种分析和工具。ERIC寻求与科学界保持紧密合作,以便我们能够持续识别并纳入最新的研究数据、工具和培训,以最好地满足肠道病原体研究界当前和未来的需求。根据NIAID合同开发的所有工具和数据都将免费提供。如需更多信息,请联系info@ericbrc.org。

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