鼠疫耶尔森菌与小肠结肠炎耶尔森菌O:8在YopJ/YopP依赖性功能方面的差异。
Disparity between Yersinia pestis and Yersinia enterocolitica O:8 in YopJ/YopP-dependent functions.
作者信息
Zauberman Ayelet, Velan Baruch, Mamroud Emanuelle, Flashner Yehuda, Shafferman Avigdor, Cohen Sara
机构信息
Department of Biochemistry and Molecular Genetics, Israel Institute for Biological Research, Ness-Ziona.
出版信息
Adv Exp Med Biol. 2007;603:312-20. doi: 10.1007/978-0-387-72124-8_28.
YopP in Y. enterocolitica and YopJ in Y. pseudotuberculosis, have been shown to exert a variety of adverse effects on cell signaling leading to suppression of cytokine expression and induction of programmed cell death. A comparative in vitro study with Y. pestis and Y. enterocolitica O:8 virulent strains shows some critical disparity in YopJ/YopP-related effects on immune cells. Involvement of yopJ in virulence was evaluated in mouse model of bubonic plague.
小肠结肠炎耶尔森菌中的YopP和假结核耶尔森菌中的YopJ已被证明会对细胞信号传导产生多种不利影响，导致细胞因子表达受到抑制以及程序性细胞死亡的诱导。一项针对鼠疫耶尔森菌和小肠结肠炎耶尔森菌O:8强毒株的体外比较研究显示，YopJ/YopP对免疫细胞的影响存在一些关键差异。在腺鼠疫小鼠模型中评估了yopJ在毒力中的作用。
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