通过对映选择性还原-Heck反应合成手性3-取代茚满酮。
Synthesis of chiral 3-substituted indanones via an enantioselective reductive-Heck reaction.
作者信息
Minatti Ana, Zheng Xiaolai, Buchwald Stephen L
机构信息
Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
出版信息
J Org Chem. 2007 Nov 23;72(24):9253-8. doi: 10.1021/jo701741y. Epub 2007 Oct 30.
PMID:17967034
Abstract
An efficient intramolecular palladium-catalyzed, asymmetric reductive-Heck reaction has been developed, which allowed for the synthesis of either enantiomerically enriched 3-substituted indanones or alpha-exo-methylene indanones depending on the base used.
摘要
已开发出一种高效的分子内钯催化不对称还原-Heck反应，该反应可根据所使用的碱合成对映体富集的3-取代茚满酮或α-外亚甲基茚满酮。
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