Oxtoby Lucas J, Gurak John A, Wisniewski Steven R, Eastgate Martin D, Engle Keary M
Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, United States.
Chemical & Synthetic Development, Bristol-Myers Squibb, 1 Squibb Drive, New Brunswick, New Jersey 08903, United States.
Trends Chem. 2019 Sep;1(6):572-587. doi: 10.1016/j.trechm.2019.05.007. Epub 2019 Jun 20.
The Mizoroki-Heck reaction is one of the most studied palladium-catalyzed cross-coupling reactions, representing a powerful method for forming C-C bonds between diverse substrates with broad functional group compatibility. However, the reductive variant has received considerably less attention. In this Review, we summarize distinct mechanistic aspects of the reductive Heck reaction, highlight recent contributions to the field, and discuss potential applications of the reductive Heck reaction in the pharmaceutical industry. With the potential to have a large impact in both academic and industrial settings, further development of the reductive Heck reaction is a promising area of future investigation.
宫泽-赫克反应是研究最多的钯催化交叉偶联反应之一，是一种在具有广泛官能团兼容性的不同底物之间形成碳-碳键的强大方法。然而，还原变体受到的关注要少得多。在本综述中，我们总结了还原赫克反应的不同机理方面，突出了该领域的最新贡献，并讨论了还原赫克反应在制药行业的潜在应用。由于还原赫克反应在学术和工业领域都有可能产生重大影响，因此该反应的进一步发展是未来一个有前景的研究领域。
