绝经后骨质疏松症患者血清骨钙素水平降低。

Decreased serum osteocalcin levels in patients with postmenopausal osteoporosis.

作者信息

Pietschmann P, Resch H, Krexner E, Woloszczuk W, Willvonseder R

机构信息

Department of Medicine II, University of Vienna, Austria.

出版信息

Acta Med Austriaca. 1991;18(5):114-6.

PMID:1796722

Abstract

Osteocalcin is a 49 amino acid non collagenous bone matrix protein which is synthesized by the osteoblasts. The serum levels of osteocalcin have been found to be a specific biochemical parameter of bone formation. We determined the serum levels of osteocalcin, parathyroid hormone, calcitonin and alkaline phosphatase as well as the 2 hour fasting hydroxyproline excretion in 26 patients with postmenopausal osteoporosis and in 24 postmenopausal control subjects. Serum levels of osteocalcin were significantly lower in the patients with postmenopausal osteoporosis than in the control subjects (p less than 0.002). In contrast, serum levels of parathyroid hormone, calcitonin, alkaline phosphatase and the 2 hour hydroxyproline excretion in the patients with postmenopausal osteoporosis and the control subjects were not statistically different. Our data give evidence of a decreased bone formation in patients with postmenopausal osteoporosis.

摘要

骨钙素是一种由成骨细胞合成的含49个氨基酸的非胶原蛋白骨基质蛋白。骨钙素的血清水平已被发现是骨形成的一个特定生化参数。我们测定了26例绝经后骨质疏松症患者和24例绝经后对照者的骨钙素、甲状旁腺激素、降钙素和碱性磷酸酶的血清水平，以及禁食2小时后的羟脯氨酸排泄量。绝经后骨质疏松症患者的骨钙素血清水平显著低于对照者（p<0.002）。相比之下，绝经后骨质疏松症患者和对照者的甲状旁腺激素、降钙素、碱性磷酸酶血清水平以及2小时羟脯氨酸排泄量在统计学上无差异。我们的数据证明绝经后骨质疏松症患者的骨形成减少。