Keskin Murat, Avul Sercan, Beyaz Aylin, Koca Nizameddin
Department of Gastroenterology, Medicana Private Hospital, Bursa, Turkey.
Department of Internal Medicine, Birecik State Hospital, Şanlıurfa, Turkey.
Heliyon. 2024 Mar 5;10(5):e27291. doi: 10.1016/j.heliyon.2024.e27291. eCollection 2024 Mar 15.
This comprehensive study delves into the potential link between Neuromedin U (NmU) serum levels and the development of non-alcoholic fatty liver disease (NAFLD), a condition of increasing global prevalence and significant public health concern. The research provides a nuanced understanding of the disease's etiology by examining a cohort of 112 participants, including individuals with and without NAFLD. The study meticulously considers a spectrum of variables such as demographic factors, body composition metrics, and blood parameters. Advanced diagnostic tools like Fibroscan® are employed to ascertain NAFLD presence, ensuring accurate and reliable results. The investigation reveals a noteworthy correlation between NAFLD and several risk factors, notably obesity, increased waist and neck circumferences, hypertriglyceridemia, and insulin resistance. These findings underscore the multifactorial nature of NAFLD and its intricate connection with metabolic syndromes. Intriguingly, the study observes lower NmU levels in individuals diagnosed with NAFLD. However, the role of NmU as an independent risk factor for NAFLD remains inconclusive, warranting further investigation. Although triglyceride level was observed to be an independent risk factor for NAFLD, this relationship was not associated with NmU. This research contributes significantly to the existing knowledge on NAFLD, highlighting the disease's complexity and the interplay of various risk factors. It also opens up new avenues for future research, particularly in exploring the role of NmU within the metabolic pathways associated with NAFLD. The insights gained from this study could guide the development of novel diagnostic and therapeutic strategies for NAFLD, addressing a crucial need in contemporary healthcare. In conclusion, the findings of this study not only enhance the understanding of NAFLD's pathophysiology but also emphasize the importance of comprehensive risk factor analysis in the management and prevention of this growing health concern.
这项全面的研究深入探讨了神经介素U（NmU）血清水平与非酒精性脂肪性肝病（NAFLD）发展之间的潜在联系。非酒精性脂肪性肝病在全球的患病率不断上升，是一个重大的公共卫生问题。该研究通过对112名参与者进行队列研究，包括患有和未患有NAFLD的个体，对该疾病的病因进行了细致入微的了解。该研究精心考虑了一系列变量，如人口统计学因素、身体成分指标和血液参数。采用了Fibroscan®等先进的诊断工具来确定NAFLD的存在，以确保结果准确可靠。调查发现NAFLD与几个风险因素之间存在显著相关性，特别是肥胖、腰围和颈围增加、高甘油三酯血症和胰岛素抵抗。这些发现强调了NAFLD的多因素性质及其与代谢综合征的复杂联系。有趣的是，该研究观察到被诊断患有NAFLD的个体中NmU水平较低。然而，NmU作为NAFLD独立风险因素的作用仍不明确，需要进一步研究。虽然观察到甘油三酯水平是NAFLD的独立风险因素，但这种关系与NmU无关。这项研究对现有关于NAFLD的知识做出了重大贡献，突出了该疾病的复杂性以及各种风险因素之间的相互作用。它还为未来的研究开辟了新途径，特别是在探索NmU在与NAFLD相关的代谢途径中的作用方面。从这项研究中获得的见解可以指导NAFLD新型诊断和治疗策略的开发，满足当代医疗保健中的一项关键需求。总之，这项研究的结果不仅增进了对NAFLD病理生理学的理解，还强调了在管理和预防这一日益严重的健康问题中进行全面风险因素分析的重要性。
