Lundorff Tina, Andresen Jens Lundgaard
Regionshospitalet Holstebro, Øjenafdelingen, Holstebro.
Ugeskr Laeger. 2007 Oct 22;169(43):3677-8.
Quinine is widely used in the treatment of nocturnal leg cramps in the elderly, despite the limited evidence of efficacy. The potential toxicity in an overdose is well known and associated with severe ocular complications. We report a 32-year-old woman with quinine induced permanent bilateral visual loss after ingesting 8.4-12.6 grams of quinine over a period of three weeks. We discuss the use of quinine as an over-the-counter drug.
尽管疗效证据有限,但奎宁仍广泛用于治疗老年人夜间腿部痉挛。过量使用时的潜在毒性是众所周知的,且与严重的眼部并发症有关。我们报告一名32岁女性,在三周内摄入8.4 - 12.6克奎宁后,因奎宁导致永久性双侧视力丧失。我们讨论了奎宁作为非处方药的使用情况。