Cormack Robert A, Holloway Caroline L, O'Farrell Desmond, Devlin Phillip M
Division of Brachytherapy, Department of Radiation Oncology, Dana Farber/Brigham and Women's Cancer Center, Boston, MA 02215, USA.
Int J Radiat Oncol Biol Phys. 2007 Nov 15;69(4):1310-5. doi: 10.1016/j.ijrobp.2007.07.2367.
To provide dosimetric information about permanent planar (125)I implants in a manner that is useful to the brachytherapist in the operative setting.
Reference planar permanent implants were simulated for a variety of areas with sources placed uniformly on a 1-cm grid. Implants having variable source spacing and curvature were simulated and compared with the reference implants. Dosimetric measures were calculated at 0.5 and 1.0 cm from the implant plane.
A method for calculating dosimetric statistics for permanent implants ranging from 5 x 5 cm to 13 x 13 cm is presented. A formula to predict the reference source strength needed to achieve a desired dosimetric quantity is also presented. The effect of adjusting strand spacing to compensate for source activity is presented and is shown to be an effective means to adjust implants to use source strengths other than the reference strength. The effect of implant curvature compared with flat implants on dosimetric statistics is presented as a function of radius of curvature.
The results presented in this work may be used to provide information about dose delivered from planar permanent implants.
以一种在手术环境中对近距离放射治疗师有用的方式，提供关于永久性平面（125）I植入物的剂量学信息。
针对各种区域模拟参考平面永久性植入物，源均匀放置在1厘米的网格上。模拟了具有可变源间距和曲率的植入物，并与参考植入物进行比较。在距植入平面0.5厘米和1.0厘米处计算剂量学测量值。
提出了一种计算5×5厘米至13×13厘米永久性植入物剂量学统计数据的方法。还给出了一个公式，用于预测实现所需剂量学量所需的参考源强度。展示了调整线束间距以补偿源活性的效果，结果表明这是一种调整植入物以使用除参考强度以外的源强度的有效方法。给出了与扁平植入物相比，植入物曲率对剂量学统计数据的影响，该影响是作为曲率半径的函数呈现的。
本研究给出的结果可用于提供关于平面永久性植入物所传递剂量的信息。
