Balion Cynthia M, Santaguida Pasqualina, McKelvie Robert, Hill Stephen A, McQueen Matthew J, Worster Andrew, Raina Parminder S
Hamilton Regional Laboratory Medicine Program, Hamilton, ON, Canada.
Clin Biochem. 2008 Mar;41(4-5):231-9. doi: 10.1016/j.clinbiochem.2007.10.005. Epub 2007 Oct 16.
To gain a better understanding of the scope and breadth of factors associated with the B-type natriuretic peptides.
Databases were searched from 1989 to February 2005 for primary studies that measured BNP or NT-proBNP for the purpose of diagnosis, prognosis and monitoring treatment.
There were 103 factors identified in 72 studies. Most of the cardiac diseases were positively associated with BNP and NT-proBNP concentrations and of the non-cardiac conditions, dyspnea, diabetic nephropathy, and stroke were all associated with higher concentrations. Most biochemical and hematological markers showed positive associations. Factors that assessed heart function showed both positive and negative associations and drug therapy was either negatively associated or had no effect on BNP or BNT-proBNP concentrations. Few studies reported independent associations and of those that did age, female gender, and creatinine concentrations were positively associated with BNP and NT-proBNP.
Various factors were found to be associated with BNP and NT-proBNP.
更好地了解与B型利钠肽相关的因素的范围和广度。
检索1989年至2005年2月的数据库，查找为诊断、预后和监测治疗而测量BNP或NT-proBNP的原始研究。
72项研究中确定了103个因素。大多数心脏病与BNP和NT-proBNP浓度呈正相关，在非心脏疾病中，呼吸困难、糖尿病肾病和中风均与较高浓度相关。大多数生化和血液学标志物呈正相关。评估心脏功能的因素既有正相关也有负相关，药物治疗与BNP或BNT-proBNP浓度呈负相关或无影响。很少有研究报告独立关联，其中年龄、女性性别和肌酐浓度与BNP和NT-proBNP呈正相关。
发现多种因素与BNP和NT-proBNP相关。
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