高剂量美法仑与干细胞移植治疗AL淀粉样变性概述

An overview of high-dose melphalan and stem cell transplantation in the treatment of AL amyloidosis.

作者信息

Sanchorawala Vaishali, Seldin David C

机构信息

Section of Hematology/Oncology in the Department of Medicine, Boston University Medical Center, Boston, MA 02118, USA.

出版信息

Amyloid. 2007 Dec;14(4):261-9. doi: 10.1080/13506120701613984.

DOI:10.1080/13506120701613984

PMID:17968685

Abstract

AL amyloidosis is the most common form of systemic amyloidosis and is associated with an underlying plasma cell dyscrasia. This review outlines an overview of high-dose intravenous melphalan and stem cell transplantation in the treatment of AL amyloidosis. An algorithm of our recommendations for the treatment of AL amyloidosis is also outlined.

摘要

AL淀粉样变性是系统性淀粉样变性最常见的形式，与潜在的浆细胞发育异常相关。本综述概述了大剂量静脉注射美法仑和干细胞移植治疗AL淀粉样变性的概况。还概述了我们对AL淀粉样变性治疗的推荐算法。