[抗结核治疗导致致命性肝衰竭病例]
[Case of fatal liver failure due to anti-tuberculous therapy].
作者信息
Harada Yoshitaka, Kawakami Kenji, Koyama Kazuhiko, Yamaryo Takeshi, Kimura Yumiko
机构信息
Department of Respiratory Medicine, National Hospital Organization Nagasaki Medical Center of Neurology, 2005-1, Shimogumigou, Kawatana-cho, Higashisonogi-gun, Nagasaki 859-3615, Japan.
出版信息
Kekkaku. 2007 Sep;82(9):705-9.
A 65-year-old female was started anti-tuberculous therapy for her pulmonary tuberculosis on admission. Liver dysfunction had occurred on 33rd day after starting treatment. AST was elevated to 301 IU/L, and ALT was also elevated to 141 IU/L. Therefore, all medicated drugs were stopped. She had jaundice on 42nd day and liver failure deteriorated. She was medicated with steroids, but she died by liver failure on 64th day. This is a rare case of fatal liver failure due to antituberculous therapy.
一名65岁女性入院时开始接受抗结核治疗以治疗肺结核。治疗开始后第33天出现肝功能障碍。谷草转氨酶（AST）升高至301 IU/L，谷丙转氨酶（ALT）也升高至141 IU/L。因此，停用了所有药物。第42天她出现黄疸，肝功能衰竭恶化。她接受了类固醇治疗，但在第64天因肝功能衰竭死亡。这是一例罕见的抗结核治疗导致的致命性肝功能衰竭病例。
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