Garg R, Mehra Sumit, Prasad R
Department of Pulmonary Medicine, Chhatrapati Sahuji Maharaj Medical University, Lucknow, Uttar Pradesh.
Indian J Tuberc. 2009 Jan;56(1):51-4.
Gynaecomastia due to anti-tubercular chemotherapy is a rare side effect. Isoniazid causing breast tissue enlargement has been very rarely reported. We report a 60-year old, male patient of Pulmonary Tuberculosis who was started on antituberculous treatment (ATT) with rifampicin (R), isoniazid (H), ethambutol (E) and pyrazinamide (Z) together for initial two months and R, H & E thereon. After five months of initiation of treatment, while receiving RHE, he developed painful bilateral gynaecomastia. Isoniazid was stopped and patient was continued on R & E till completion of the treatment up to nine months. After stopping isoniazid, his breast swelling subsided to some extent and became non-tender. Follow up, at six months, after stopping the course of treatment, patient was asymptomatic except for slight bilateral non-tender breast enlargement.
抗结核化疗所致男性乳房发育是一种罕见的副作用。异烟肼导致乳腺组织增大的情况鲜有报道。我们报告一例60岁男性肺结核患者，最初两个月接受利福平（R）、异烟肼（H）、乙胺丁醇（E）和吡嗪酰胺（Z）联合抗结核治疗，之后继续使用R、H和E。治疗开始五个月后，在接受RHE治疗时，他出现双侧疼痛性男性乳房发育。停用异烟肼，患者继续使用R和E直至九个月疗程结束。停用异烟肼后，他的乳房肿胀有所消退且不再疼痛。治疗疗程结束六个月后的随访显示，患者除双侧乳房轻度无痛性增大外无任何症状。
