Lockman L A, Sung J H, Krivit W
Division of Pediatric, University of Minnesota Medical School, Minneapolis.
Pediatr Neurol. 1991 Nov-Dec;7(6):457-63. doi: 10.1016/0887-8994(91)90031-f.
A syndrome of rigidity, bradykinesia, spasticity, and often myoclonus and dementia developed acutely in 5 patients who had undergone successful engraftment of bone marrow transplants for the treatment of various hematologic diseases. Magnetic resonance imaging demonstrated widespread changes in white matter; brain biopsy disclosed mild demyelination associated with active phagocytosis of myelin. One patient, who was not treated, remains severely demented. Patients treated with very high-dose methylprednisolone had complete clinical recovery.
5名因治疗各种血液系统疾病而成功接受骨髓移植的患者急性出现了一种综合征，表现为强直、运动迟缓、痉挛，常伴有肌阵挛和痴呆。磁共振成像显示白质广泛改变；脑活检显示轻度脱髓鞘，并伴有髓鞘的活跃吞噬。1名未接受治疗的患者仍严重痴呆。接受大剂量甲泼尼龙治疗的患者临床完全康复。
