Jakobson A M
Department of Pediatrics, University of Uppsala, Sweden.
Biol Neonate. 1991;60(3-4):221-9. doi: 10.1159/000243412.
The postnatal development of bilirubin accumulation by the choroid plexus was studied in vitro. Choroid plexus of the fourth and lateral cerebral ventricles from adult or 1-, 7-, 15- or 21-day-old rabbits were incubated in a potassium-rich medium with 70 nmol/l of 3H-bilirubin for 5 min. The tissue/medium (T/M) ratio for 3H-bilirubin was considerable even 1 day post partum and increased during the next 2-3 weeks of life. In adults the 3H-bilirubin T/M ratio returned to the level of 1-day-old rabbits. The biliary excreted contrast agent iodipamide, added as a transport inhibitor, reduced the 3H-bilirubin T/M ratio in the choroid plexus, but to a relatively lesser extent in the 1-day-old rabbits than in the older ones.
我们在体外研究了脉络丛中胆红素积累的产后发育情况。将成年或1日龄、7日龄、15日龄或21日龄兔子的第四脑室和侧脑室脉络丛在富含钾的培养基中与70 nmol/L的3H-胆红素一起孵育5分钟。即使在产后1天，3H-胆红素的组织/培养基（T/M）比值也相当可观，并在接下来的2 - 3周生命中增加。在成年兔子中，3H-胆红素T/M比值恢复到1日龄兔子的水平。作为转运抑制剂添加的经胆汁排泄的造影剂碘番酸降低了脉络丛中3H-胆红素的T/M比值，但在1日龄兔子中降低的程度相对小于年龄较大的兔子。
