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谷胱甘肽S-转移酶制剂的抗毒特性

Antitoxic properties of a preparation of glutathione S-transferase.

作者信息

Kalinina E V, Nechaev V N, Saprin A N

机构信息

All-Union Research Institute of Biotechnology, Ministry of Medical Industry of the USSR, Moscow.

出版信息

Biomed Sci. 1991;2(4):415-6.

PMID:1797146
Abstract

Pretreatment of rats with a preparation of the cationic form of rat liver cytosolic glutathione S-transferase 1-3 h before injection of a dose of N-nitroso-N-diethylamine equivalent to the LD50 of the drug completely protects the animals against the toxic effects of the drug. The mechanism of the protective action of glutathione S-transferase is discussed.

摘要

在注射相当于药物半数致死量的N-亚硝基-N-二乙胺之前1 - 3小时，用阳离子形式的大鼠肝细胞溶质谷胱甘肽S-转移酶制剂对大鼠进行预处理，可使动物完全免受该药物的毒性作用。文中讨论了谷胱甘肽S-转移酶的保护作用机制。

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Antitoxic properties of a preparation of glutathione S-transferase.谷胱甘肽S-转移酶制剂的抗毒特性
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