[羟基（对甲苯磺酰氧基）碘]苯介导的酮的α-叠氮化反应。
[Hydroxy(tosyloxy)iodo]benzene mediated alpha-azidation of ketones.
作者信息
Prakash Om, Pannu Kamaljeet, Prakash Richa, Batra Anita
机构信息
Department of Chemistry, Kurukshetra University, Kurukshetra, Haryana, India.
出版信息
Molecules. 2006 Jul 14;11(7):523-7. doi: 10.3390/11070523.
Abstract
Reaction of various ketones with [hydroxy(tosyloxy)iodo]benzene (HTIB) followed by treatment of the alpha-tosyloxy ketones thus generated in situ with NaN3 offers a one-pot procedure for the synthesis of alpha-azido ketones. The HTIB used in this conversion may also be generated in situ by using iodosobenzene in combination with p-toluene-sulphonic acid.
摘要
各种酮与[羟基（对甲苯磺酰氧基）碘]苯（HTIB）反应，然后用叠氮化钠处理原位生成的α-对甲苯磺酰氧基酮，为α-叠氮基酮的合成提供了一种一锅法。此转化过程中使用的HTIB也可通过将亚碘酰苯与对甲苯磺酸结合原位生成。
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