通过[羟基（对甲苯磺酰氧基）碘]苯（HTIB）介导的氧化 N-O 偶联合成异恶唑啉 N-氧化物。
Synthesis of isoxazoline N-oxides via [hydroxy(tosyloxy)iodo]benzene (HTIB)-mediated oxidative N-O coupling.
机构信息
Department of Chemistry, National Taiwan Normal University, 88, Sec. 4, Tingchow Road, Taipei, Taiwan 116, Republic of China.
出版信息
J Org Chem. 2011 Jan 21;76(2):424-34. doi: 10.1021/jo1018393. Epub 2010 Dec 22.
PMID:21175154
Abstract
An HTIB mediated oxidative N-O coupling strategy for the synthesis of some isoxazoline N-oxide derivatives from β-hydroxyketoximes is described, along with a comparative study of the efficiency of N-O coupling in two different solvents. A plausible mechanism for the conversion is proposed.
摘要
本文描述了一种通过 HTIB 介导的氧化 N-O 偶联策略，从β-羟基酮肟合成一些异噁唑啉 N-氧化物衍生物，并对两种不同溶剂中 N-O 偶联效率进行了比较研究。提出了一种可能的转化机制。
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