Odzak Renata, Tomic Srdjanka
Department of Chemistry, Faculty of Natural Sciences, Mathematics and Education, University of Split, N. Tesle 12, 21 000 Split, Croatia.
Molecules. 2006 Sep 28;11(9):726-30. doi: 10.3390/11090726.
The synthesis of racemic and enantiomerically pure N-p-methylbenzyl-3- and N-p-chlorobenzylbenzamidoquinuclidinium bromides (6-8 and 9-11, respectively) is described. These compounds were prepared from racemic or enantiomerically pure 3-benzamidoquinuclidines 3-5 using the appropriate quaternization reagents: p-methyl- benzyl bromide (1) and p-chlorobenzyl bromide (2).
描述了外消旋和对映体纯的N - 对甲基苄基 - 3 - 和N - 对氯苄基苯甲酰基奎宁环溴化物(分别为6 - 8和9 - 11)的合成。这些化合物是由外消旋或对映体纯的3 - 苯甲酰基奎宁环3 - 5使用适当的季铵化试剂:对甲基苄基溴(1)和对氯苄基溴(2)制备而成的。