Hagiwara A, Takahashi T, Iwamoto A, Yoneyama C, Ito M, Sasabe T, Muranishi S, Matsumoto S
First Department of Surgery, Kyoto Prefectural University of Medicine, Japan.
Anticancer Drugs. 1991 Aug;2(4):365-9. doi: 10.1097/00001813-199108000-00005.
A new dosage form (ACR-CH), a suspension of small activated carbon particles adsorbing aclarubicin, was studied for its toxicity and histopathological effects on organs in mice. The 50% lethal subcutaneous dose of ACR-CH was 83.5 mg/kg, a value 2.42 times that (34.5 mg/kg) of the aclarubicin aqueous solution. The duration of the toxic effects of ACR-CH was prolonged compared with that of the aclarubicin aqueous solution. On autopsy there was no remarkable difference in macroscopic and microscopic examinations between the two dosage forms.
研究了一种新剂型（ACR-CH），即吸附阿克拉霉素的小活性炭颗粒悬浮液，观察其对小鼠器官的毒性和组织病理学影响。ACR-CH的50%皮下致死剂量为83.5毫克/千克，该数值是阿克拉霉素水溶液（34.5毫克/千克）的2.42倍。与阿克拉霉素水溶液相比，ACR-CH的毒性作用持续时间延长。尸检时，两种剂型在大体和显微镜检查方面均无明显差异。
