[重症急性呼吸综合征患者外周血纤维蛋白原水平的变化及意义]
[Changes and significance of peripheral blood fibrinogen level in patients with severe acute respiratory syndrome].
作者信息
Gou Chun-Yan, Li Xiu-Hui, Liang Lian-Chun, Qi Jing
机构信息
Beijing You'an Hospital Affiliated to Capital University of Medical Sciences, Beijing, China.
出版信息
Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2007 Sep;21(3):258-60.
OBJECTIVE
To investigate variations and significance of plasma fibrinogen in patients with severe acute respiratory syndrome (SARS).
METHODS
Totally 148 patients with SARS were divided into the following groups: initial stage group (44 cases) and after the initial stage group (104 cases), common type group (87 cases) and severe type group (61 cases), unilobar lung involvement group (49 cases), bilobar lung involvement group (53 cases) and diffuse lung involvement group (46 cases). The values of plasma fibrinogen of the 148 SARS patients were analyzed and compared among the different groups.
RESULTS
The mean value of plasma fibrinogen (x +/- SD, 522.29 +/- 154.87 mg/dl) of the 148 cases was higher than the normal value (p less than 0.01). There were significant differences between the initial stage and after initial stage groups, between the common and severe type groups, and among the unilobar, bilobar and diffuse lung involvement groups (p less than 0.05).
CONCLUSION
theses results suggested that elevation of peripheral blood fibrinogen in SARS patients may play an important role in development and progress of the disease and its treatment.
目的
探讨严重急性呼吸综合征（SARS）患者血浆纤维蛋白原的变化及其意义。
方法
将148例SARS患者分为初期组（44例）和初期后组（104例），普通型组（87例）和重型组（61例），单叶肺受累组（49例）、双叶肺受累组（53例）和弥漫性肺受累组（46例）。分析比较148例SARS患者不同组间血浆纤维蛋白原水平。
结果
148例患者血浆纤维蛋白原平均值（x±SD，522.29±154.87mg/dl）高于正常水平（P＜0.01）。初期组与初期后组、普通型组与重型组、单叶肺受累组、双叶肺受累组和弥漫性肺受累组之间差异有统计学意义（P＜0.05）。
结论
这些结果提示SARS患者外周血纤维蛋白原升高可能在疾病的发生发展及治疗中起重要作用。
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