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苯并咪唑和苯并噻唑醌：NAD(P)H：醌氧化还原酶1的优良底物。

Benzimidazole- and benzothiazole-quinones: excellent substrates for NAD(P)H:quinone oxidoreductase 1.

作者信息

Newsome Jeffery J, Colucci Marie A, Hassani Mary, Beall Howard D, Moody Christopher J

机构信息

Department of Chemistry, University of Exeter, Stocker Road, Exeter, UK.

出版信息

Org Biomol Chem. 2007 Nov 21;5(22):3665-73. doi: 10.1039/b713044a. Epub 2007 Oct 8.

DOI:10.1039/b713044a
PMID:17971996
Abstract

A series of benzimidazole- and benzothiazole-quinones has been synthesized. The ability of these heterocyclic quinones to act as substrates for recombinant human NAD(P)H:quinone oxidoreductase (NQO1), a two-electron reductase upregulated in tumour cells, was determined. Overall, the quinones were excellent substrates for NQO1.

摘要

已合成了一系列苯并咪唑和苯并噻唑醌。测定了这些杂环醌作为重组人NAD(P)H:醌氧化还原酶（NQO1，一种在肿瘤细胞中上调的双电子还原酶）底物的能力。总体而言，这些醌是NQO1的优良底物。

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