多发性硬化症中HLA - DRB1*15的亲代传递
Parental transmission of HLA-DRB1*15 in multiple sclerosis.
作者信息
Ramagopalan Sreeram V, Herrera Blanca M, Bell Jordana T, Dyment David A, Deluca Gabriele C, Lincoln Matthew R, Orton Sarah M, Chao Michael J, Sadovnick A Dessa, Ebers George C
机构信息
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.
出版信息
Hum Genet. 2008 Jan;122(6):661-3. doi: 10.1007/s00439-007-0442-z. Epub 2007 Oct 31.
Multiple sclerosis (MS) is a complex trait in which HLA-DRB115 bearing MHC haplotypes increase risk of MS in people of Northern European descent. In this investigation of 7,334 individuals from 1,515 MS families, the largest cohort used to study the HLA-DRB1 locus to date, we analysed the transmission of HLA-DRB115 haplotypes stratified by sex of transmitting parent. A significant over transmission of HLA-DRB1*15 from mothers was observed (chi (2) = 7.73, P = 0.0054), suggesting that parent of origin effects at the MHC determine susceptibility to MS.
多发性硬化症（MS）是一种复杂性状，其中携带MHC单倍型的HLA - DRB115会增加北欧血统人群患MS的风险。在这项对来自1515个MS家庭的7334名个体的研究中，这是迄今为止用于研究HLA - DRB1基因座的最大队列，我们分析了按传递亲本性别分层的HLA - DRB115单倍型的传递情况。观察到HLA - DRB1*15从母亲的传递显著过度（卡方值 = 7.73，P = 0.0054），这表明MHC的亲本来源效应决定了对MS的易感性。
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