Parental non-inherited HLA resistance alleles do not confer protection against multiple sclerosis.

作者信息

Ramagopalan Sreeram V, Dyment David A, Herrera Blanca M, DeLuca Gabriele C, Lincoln Matthew R, Orton Sarah M, Handunnetthi Lahiru, Chao Michael J, Dessa Sadovnick A, Ebers George C

机构信息

Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.

出版信息

J Neuroimmunol. 2008 May 30;196(1-2):170-2. doi: 10.1016/j.jneuroim.2008.03.005. Epub 2008 Apr 22.

DOI:10.1016/j.jneuroim.2008.03.005

PMID:18433881

Abstract

Multiple sclerosis (MS) is a complex trait in which alleles at or near the class II loci HLA-DRB1 and HLA-DQB1 contribute significantly to genetic risk. HLA-DRB114 and DRB111 bearing haplotypes protect against MS and DRB101 and DRB110 interact with DRB115 to reduce risk of the disease. Recent work in other autoimmune diseases such as rheumatoid arthritis has suggested that maternal non-transmitted protective alleles can also confer disease resistance. In this investigation of 7093 individuals from 1432 MS families, we have analysed the transmission of HLA-DRB114,*11,*10 and *01 haplotypes, stratified by sex of parent. No significant transmission differences between mothers and fathers were found, suggesting that non-inherited resistance alleles do not appear to play a role in MS.

摘要