一例起源于广泛鼻神经胶质瘤病背景下的鼻窦未分化癌病例报告。
Report of a case of sinonasal undifferentiated carcinoma arising in a background of extensive nasal gliomatosis.
作者信息
Tetzlaff Michael T, Liu Peter, O'Malley Bert W, LiVolsi Virginia A, Elder David
机构信息
Department of Pathology and Laboratory Medicine, Hospital for the University of Pennsylvania, 3400 Spruce Street, Philadelphia, Pennsylvania, USA.
出版信息
Head Neck. 2008 Apr;30(4):549-55. doi: 10.1002/hed.20707.
BACKGROUND
Sinonasal undifferentiated carcinoma (SNUC) is a relatively rare, aggressive malignancy of adulthood. Nasal glial heterotopia is a benign congenital condition in which mature benign brain tissue develops outside the central nervous system.
METHODS
A 37-year-old man was seen with right nasal obstruction, epistaxis, and headache. Imaging showed a radiologically malignant mass lesion. Biopsy and subsequent resection were performed in the evaluation and treatment of this lesion. Histologic and immunohistochemical assessments of the biopsy and resection specimens on the pathology material classified the lesional tissue.
RESULTS
Histology and immunohistochemistry of the biopsy specimen demonstrated an SNUC that was subsequently resected following chemotherapy. In addition to SNUC, the resection specimen revealed extensive, multifocal nasal glial heterotopia (so called "nasal glioma").
CONCLUSIONS
This is the first known case in the literature in which these 2 relatively rare entities coincide.
背景
鼻窦未分化癌（SNUC）是一种相对罕见的成人侵袭性恶性肿瘤。鼻胶质异位是一种良性先天性疾病，其中成熟的良性脑组织在中枢神经系统外发育。
方法
一名37岁男性因右侧鼻塞、鼻出血和头痛前来就诊。影像学检查显示一个放射学上的恶性肿块病变。在对该病变进行评估和治疗时进行了活检及后续切除。对病理材料中的活检和切除标本进行组织学和免疫组化评估以对病变组织进行分类。
结果
活检标本的组织学和免疫组化显示为鼻窦未分化癌，随后在化疗后进行了切除。除了鼻窦未分化癌，切除标本还显示广泛的多灶性鼻胶质异位（所谓的“鼻胶质瘤”）。
结论
这是文献中首次报道的这两种相对罕见的病变同时存在的病例。
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