Brandt Dominique T, Grosse Robert
Institute of Pharmacology, University of Heidelberg, Im Neuenheimer Feld 366, 69120 Heidelberg, Germany.
EMBO Rep. 2007 Nov;8(11):1019-23. doi: 10.1038/sj.embor.7401089.
IQGAPs are actin-binding proteins that scaffold numerous interaction partners, transmitting extracellular signals that influence mitogenic, morphological and migratory cell behaviour. However, the precise mechanisms by which IQGAP proteins influence actin dynamics and actin filament structures have been elusive. Now that IQGAP1 has emerged as a potential key regulator of actin-cytoskeletal dynamics by recruiting both the actin related protein (Arp)2/3 complex and/or formin-dependent actin polymerizing machineries, we propose that IQGAP1 might coordinate the function of mechanistically different actin nucleators for cooperative localized actin filament production in various cellular processes.
IQGAP 蛋白是肌动蛋白结合蛋白，可作为众多相互作用伙伴的支架，传递影响有丝分裂、细胞形态和迁移行为的细胞外信号。然而，IQGAP 蛋白影响肌动蛋白动力学和肌动蛋白丝结构的确切机制一直难以捉摸。鉴于 IQGAP1 通过招募肌动蛋白相关蛋白（Arp）2/3 复合物和 / 或formin 依赖性肌动蛋白聚合机制，已成为肌动蛋白细胞骨架动力学的潜在关键调节因子，我们提出 IQGAP1 可能协调机制不同的肌动蛋白成核因子的功能，以便在各种细胞过程中协同进行局部肌动蛋白丝的生成。
