掌握要点：利用IQGAPs调控局部肌动蛋白动力学
Get to grips: steering local actin dynamics with IQGAPs.
作者信息
Brandt Dominique T, Grosse Robert
机构信息
Institute of Pharmacology, University of Heidelberg, Im Neuenheimer Feld 366, 69120 Heidelberg, Germany.
出版信息
EMBO Rep. 2007 Nov;8(11):1019-23. doi: 10.1038/sj.embor.7401089.
Abstract
IQGAPs are actin-binding proteins that scaffold numerous interaction partners, transmitting extracellular signals that influence mitogenic, morphological and migratory cell behaviour. However, the precise mechanisms by which IQGAP proteins influence actin dynamics and actin filament structures have been elusive. Now that IQGAP1 has emerged as a potential key regulator of actin-cytoskeletal dynamics by recruiting both the actin related protein (Arp)2/3 complex and/or formin-dependent actin polymerizing machineries, we propose that IQGAP1 might coordinate the function of mechanistically different actin nucleators for cooperative localized actin filament production in various cellular processes.
摘要
IQGAP 蛋白是肌动蛋白结合蛋白，可作为众多相互作用伙伴的支架，传递影响有丝分裂、细胞形态和迁移行为的细胞外信号。然而，IQGAP 蛋白影响肌动蛋白动力学和肌动蛋白丝结构的确切机制一直难以捉摸。鉴于 IQGAP1 通过招募肌动蛋白相关蛋白（Arp）2/3 复合物和 / 或formin 依赖性肌动蛋白聚合机制，已成为肌动蛋白细胞骨架动力学的潜在关键调节因子，我们提出 IQGAP1 可能协调机制不同的肌动蛋白成核因子的功能，以便在各种细胞过程中协同进行局部肌动蛋白丝的生成。
相似文献
1
Get to grips: steering local actin dynamics with IQGAPs.掌握要点：利用IQGAPs调控局部肌动蛋白动力学
EMBO Rep. 2007 Nov;8(11):1019-23. doi: 10.1038/sj.embor.7401089.
2
The scaffold-protein IQGAP1 enhances and spatially restricts the actin-nucleating activity of Diaphanous-related formin 1 (DIAPH1).支架蛋白 IQGAP1 增强并空间限制了 Dia 相关形成蛋白 1（DIAPH1）的肌动蛋白成核活性。
J Biol Chem. 2020 Mar 6;295(10):3134-3147. doi: 10.1074/jbc.RA119.010476. Epub 2020 Jan 31.
3
Single-molecule imaging of IQGAP1 regulating actin filament dynamics.IQGAP1 调节肌动蛋白丝动态的单分子成像。
Mol Biol Cell. 2022 Jan 1;33(1):ar2. doi: 10.1091/mbc.E21-04-0211. Epub 2021 Nov 3.
4
IQGAP1 regulates cell motility by linking growth factor signaling to actin assembly.IQGAP1通过将生长因子信号传导与肌动蛋白组装相联系来调节细胞运动。
J Cell Sci. 2007 Feb 15;120(Pt 4):658-69. doi: 10.1242/jcs.03376. Epub 2007 Jan 30.
5
IQGAPs as Key Regulators of Actin-cytoskeleton Dynamics.IQGAPs作为肌动蛋白细胞骨架动力学的关键调节因子。
Cell Struct Funct. 2015;40(2):69-77. doi: 10.1247/csf.15003. Epub 2015 Jun 6.
6
An mDia1-INF2 formin activation cascade facilitated by IQGAP1 regulates stable microtubules in migrating cells.由IQGAP1促进的mDia1-INF2formin激活级联反应调节迁移细胞中的稳定微管。
Mol Biol Cell. 2016 Jun 1;27(11):1797-808. doi: 10.1091/mbc.E15-07-0489. Epub 2016 Mar 30.
7
Actin filament binding by a monomeric IQGAP1 fragment with a single calponin homology domain.具有单个钙调蛋白同源结构域的单体IQGAP1片段与肌动蛋白丝的结合。
Cell Motil Cytoskeleton. 2004 Aug;58(4):231-41. doi: 10.1002/cm.20013.
8
A new cytoskeletal connection for APC: linked to actin through IQGAP.一种新的APC细胞骨架连接：通过IQGAP与肌动蛋白相连。
Dev Cell. 2004 Dec;7(6):778-80. doi: 10.1016/j.devcel.2004.11.012.
9
On the Interaction Between Human IQGAP1 and Actin.关于人类IQGAP1与肌动蛋白之间的相互作用
Protein Pept Lett. 2016;23(4):386-95. doi: 10.2174/0929866523666160204123331.
10
The IQGAP1 protein is a calmodulin-regulated barbed end capper of actin filaments: possible implications in its function in cell migration.IQGAP1 蛋白是一种钙调蛋白调节的肌动蛋白丝帽状末端封盖蛋白：其在细胞迁移功能中的可能意义。
J Biol Chem. 2011 Oct 7;286(40):35119-28. doi: 10.1074/jbc.M111.258772. Epub 2011 Jul 5.
引用本文的文献
1
Wnt target IQGAP3 promotes Wnt signaling via disrupting Axin1-CK1α interaction.Wnt靶基因IQGAP3通过破坏Axin1与CK1α的相互作用来促进Wnt信号传导。
Oncogene. 2025 Aug 19. doi: 10.1038/s41388-025-03512-y.
2
Intermediate filament IFFO1 negatively regulates the migration of lung cancer cells by inhibiting the IQGAP3-Cdc42 interaction.中间丝IFFO1通过抑制IQGAP3与Cdc42的相互作用来负向调节肺癌细胞的迁移。
Cell Death Dis. 2025 Jul 10;16(1):509. doi: 10.1038/s41419-025-07846-z.
3
Coronin 1a-mediated F-actin disassembly controls effector function in murine neutrophils.冠蛋白1a介导的F-肌动蛋白解聚控制小鼠中性粒细胞的效应功能。
Redox Biol. 2025 May;82:103618. doi: 10.1016/j.redox.2025.103618. Epub 2025 Mar 26.
4
Altered structural and transporter-related gene expression patterns in the placenta play a role in fetal demise during Porcine reproductive and respiratory syndrome virus infection.猪繁殖与呼吸综合征病毒感染期间，胎盘中结构和转运蛋白相关基因表达模式的改变在胎儿死亡中起作用。
BMC Genomics. 2025 Mar 21;26(1):279. doi: 10.1186/s12864-025-11397-0.
5
Ninein isoform contributions to intracellular processes and macrophage immune function.Ninein异构体对细胞内过程和巨噬细胞免疫功能的作用。
J Biol Chem. 2025 May;301(5):108419. doi: 10.1016/j.jbc.2025.108419. Epub 2025 Mar 18.
6
In silico predicted compound targeting the IQGAP1-GRD domain selectively inhibits growth of human acute myeloid leukemia.基于计算机预测的靶向 IQGAP1-GRD 结构域的化合物选择性抑制人急性髓系白血病的生长。
Sci Rep. 2024 Jun 4;14(1):12868. doi: 10.1038/s41598-024-63392-2.
7
Proximity Mapping of Desmosomes Reveals a Striking Shift in Their Molecular Neighborhood Associated With Maturation.桥粒的近邻图谱揭示了与成熟相关的其分子邻域的显著变化。
Mol Cell Proteomics. 2024 Mar;23(3):100735. doi: 10.1016/j.mcpro.2024.100735. Epub 2024 Feb 10.
8
Ninein promotes F-actin cup formation and inward phagosome movement during phagocytosis in macrophages.Nin 在巨噬细胞的吞噬作用中促进 F-actin 杯形成和向内的吞噬体运动。
Mol Biol Cell. 2024 Mar 1;35(3):ar26. doi: 10.1091/mbc.E23-06-0216. Epub 2023 Dec 20.
9
Embedding of HIV Egress within Cortical F-Actin.HIV释放嵌入皮质肌动蛋白F-肌动蛋白中。
Pathogens. 2022 Jan 3;11(1):56. doi: 10.3390/pathogens11010056.
10
Role of actin cytoskeleton in the organization and function of ionotropic glutamate receptors.肌动蛋白细胞骨架在离子型谷氨酸受体的组织与功能中的作用
Curr Res Struct Biol. 2021 Oct 14;3:277-289. doi: 10.1016/j.crstbi.2021.10.001. eCollection 2021.
本文引用的文献
1
Impaired T lymphocyte trafficking in mice deficient in an actin-nucleating protein, mDia1.缺乏肌动蛋白成核蛋白mDia1的小鼠中T淋巴细胞运输受损。
J Exp Med. 2007 Sep 3;204(9):2031-8. doi: 10.1084/jem.20062647. Epub 2007 Aug 6.
2
Dia1 and IQGAP1 interact in cell migration and phagocytic cup formation.Dia1与IQGAP1在细胞迁移和吞噬杯形成过程中相互作用。
J Cell Biol. 2007 Jul 16;178(2):193-200. doi: 10.1083/jcb.200612071. Epub 2007 Jul 9.
3
IQGAP2 is required for the cadherin-mediated cell-to-cell adhesion in Xenopus laevis embryos.爪蟾胚胎中钙黏蛋白介导的细胞间黏附需要IQGAP2。
Dev Biol. 2007 Aug 15;308(2):485-93. doi: 10.1016/j.ydbio.2007.06.001. Epub 2007 Jun 9.
4
T cell responses in mammalian diaphanous-related formin mDia1 knock-out mice.哺乳动物中与透明相关的formin mDia1基因敲除小鼠的T细胞反应。
J Biol Chem. 2007 Aug 24;282(34):25152-8. doi: 10.1074/jbc.M703243200. Epub 2007 Jun 26.
5
IQGAP1 modulates activation of B-Raf.IQGAP1调节B-Raf的激活。
Proc Natl Acad Sci U S A. 2007 Jun 19;104(25):10465-9. doi: 10.1073/pnas.0611308104. Epub 2007 Jun 11.
6
IQGAP1 binds Rap1 and modulates its activity.IQGAP1与Rap1结合并调节其活性。
J Biol Chem. 2007 Jul 13;282(28):20752-62. doi: 10.1074/jbc.M700487200. Epub 2007 May 21.
7
IQGAP1 and IGFBP2: valuable biomarkers for determining prognosis in glioma patients.IQGAP1和IGFBP2：用于确定胶质瘤患者预后的有价值生物标志物。
J Neuropathol Exp Neurol. 2007 May;66(5):405-17. doi: 10.1097/nen.0b013e31804567d7.
8
Regulation of actin filament assembly by Arp2/3 complex and formins.Arp2/3复合体和formin对肌动蛋白丝组装的调控
Annu Rev Biophys Biomol Struct. 2007;36:451-77. doi: 10.1146/annurev.biophys.35.040405.101936.
9
IQGAP1 regulates cell motility by linking growth factor signaling to actin assembly.IQGAP1通过将生长因子信号传导与肌动蛋白组装相联系来调节细胞运动。
J Cell Sci. 2007 Feb 15;120(Pt 4):658-69. doi: 10.1242/jcs.03376. Epub 2007 Jan 30.
10
IQGAP3, a novel effector of Rac1 and Cdc42, regulates neurite outgrowth.IQGAP3是Rac1和Cdc42的一种新型效应蛋白，可调节神经突生长。
J Cell Sci. 2007 Feb 15;120(Pt 4):567-77. doi: 10.1242/jcs.03356. Epub 2007 Jan 23.
Zotero 插件