Lasalvia A, Bonetto C, Cristofalo D, Tansella M, Ruggeri M
Department of Medicine and Public Health, Section of Psychiatry and Clinical Psychology, University of Verona, Verona, Italy.
Acta Psychiatr Scand Suppl. 2007(437):16-30. doi: 10.1111/j.1600-0447.2007.01090.x.
The aims of this study were: i) to determine changes in symptoms and social disability, and ii) to explore predictors of clinical and social outcome in patients receiving community-based mental health care.
A total of 354 patients treated in the South-Verona Community Mental Health Service were followed up over 6 years (with assessments made at baseline, 2 and 6 years) by using a set of standardized measures exploring psychopathology (Brief Psychiatric Rating Scale) and social disability (Disability Assessment Schedule). Generalized linear latent and mixed models were used to explore longitudinal predictors of clinical and social outcome.
Psychotic patients displayed clinical and social outcome characterized by complex patterns of exacerbation and remission over time; however, a clear trend towards a deteriorating course was not found, thus challenging the notion that psychotics are fatally prone to a destiny of chronicity. Non-psychotics reported a significant reduction in the core symptom of depression and in the observable physical and motor manifestations of tension and agitation, and a parallel increase in complaints about their physical health. Clinical and social dimensions of outcome are influenced by specific and different set of predictors.
The results of this study confirm the need to implement naturalistic outcome studies conducted in the 'real world' services to inform decisions and strategies to be adopted in routine clinical practice.
本研究的目的是:i)确定症状和社会残疾的变化,以及ii)探索接受社区心理健康护理的患者临床和社会结局的预测因素。
对在南维罗纳社区心理健康服务中心接受治疗的354名患者进行了6年的随访(在基线、2年和6年时进行评估),使用了一套标准化措施来探究精神病理学(简明精神病评定量表)和社会残疾(残疾评定量表)。使用广义线性潜在和混合模型来探索临床和社会结局的纵向预测因素。
精神病患者的临床和社会结局表现为随时间推移出现复杂的加重和缓解模式;然而,未发现明显的病情恶化趋势,因此对精神病患者注定易患慢性病这一观念提出了挑战。非精神病患者报告称,抑郁的核心症状以及紧张和激动的明显身体和运动表现显著减少,同时对身体健康的抱怨相应增加。结局的临床和社会维度受到特定且不同的预测因素集的影响。
本研究结果证实,需要在“现实世界”服务中开展自然主义结局研究,为常规临床实践中应采用的决策和策略提供信息。