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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Kelly J J, Tam S H, Williamson P M, Whitworth J A

Department of Medicine, University of New South Wales, St George Hospital, Sydney, NSW, Australia.

Clin Exp Pharmacol Physiol. 2007 Dec;34(12):1317-8. doi: 10.1111/j.1440-1681.2007.04700.x.

Decreased nitric oxide (NO) availability is thought to be a feature of cortisol-induced hypertension in humans. 2. We hypothesized that, accordingly, the threshold for a depressor response to NO should be decreased by cortisol treatment. 3. We re-analysed data from a study of baroreflex function in normal men treated with cortisol using glyceryl trinitrate (GTN). 4. Cortisol treatment increased blood pressure and decreased the threshold dose of GTN for a fall in systolic and mean blood pressure. 5. These data support the notion that glucorticoid hypertension is associated with reduced NO bioavailability.

一氧化氮（NO）可用性降低被认为是人类皮质醇诱导性高血压的一个特征。2. 因此，我们推测，皮质醇治疗应会降低对NO降压反应的阈值。3. 我们重新分析了一项关于使用硝酸甘油（GTN）治疗的正常男性压力反射功能研究的数据。4. 皮质醇治疗使血压升高，并降低了GTN导致收缩压和平均血压下降的阈值剂量。5. 这些数据支持了糖皮质激素性高血压与NO生物利用度降低相关的观点。

Kelly J J, Tam S H, Williamson P M, Whitworth J A

Department of Medicine, University of New South Wales, St George Hospital, Sydney, NSW, Australia.

Clin Exp Pharmacol Physiol. 2007 Dec;34(12):1317-8. doi: 10.1111/j.1440-1681.2007.04700.x.

Decreased nitric oxide (NO) availability is thought to be a feature of cortisol-induced hypertension in humans. 2. We hypothesized that, accordingly, the threshold for a depressor response to NO should be decreased by cortisol treatment. 3. We re-analysed data from a study of baroreflex function in normal men treated with cortisol using glyceryl trinitrate (GTN). 4. Cortisol treatment increased blood pressure and decreased the threshold dose of GTN for a fall in systolic and mean blood pressure. 5. These data support the notion that glucorticoid hypertension is associated with reduced NO bioavailability.

一氧化氮（NO）可用性降低被认为是人类皮质醇诱导性高血压的一个特征。2. 因此，我们推测，皮质醇治疗应会降低对NO降压反应的阈值。3. 我们重新分析了一项关于使用硝酸甘油（GTN）治疗的正常男性压力反射功能研究的数据。4. 皮质醇治疗使血压升高，并降低了GTN导致收缩压和平均血压下降的阈值剂量。5. 这些数据支持了糖皮质激素性高血压与NO生物利用度降低相关的观点。