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以胰体尾部双肿块及肺转移为首发表现的1型多发性内分泌腺瘤病合并胰高血糖素瘤

Glucagonoma with two pancreatic masses and pulmonary metastases as debut of MEN-1.

作者信息

Gutiérrez V, Cobo M, Olea D, García J, Ramírez C, Bautista D, Alcalde J

机构信息

Sección de Oncología Médica. Hospital R. Universitario Carlos Haya. Málaga, Spain.

出版信息

Clin Transl Oncol. 2007 Oct;9(10):674-7. doi: 10.1007/s12094-007-0121-5.

DOI:10.1007/s12094-007-0121-5
PMID:17974529
Abstract

This is a rare case of a patient with type 1 multiple endocrine neoplasia (MEN-1) syndrome. The case is further unusual in that the glucagonoma debuted with two synchronic pancreatic masses at the time of diagnosis and with pulmonary metastases as the primary site of metastasis and not the more usual site of the liver.

摘要

这是一例罕见的1型多发性内分泌肿瘤（MEN-1）综合征患者。该病例更为特殊的是，诊断时胰高血糖素瘤首次出现两个同步的胰腺肿块，且肺转移是主要转移部位，而非更常见的肝脏。

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Glucagonoma with two pancreatic masses and pulmonary metastases as debut of MEN-1.以胰体尾部双肿块及肺转移为首发表现的1型多发性内分泌腺瘤病合并胰高血糖素瘤
Clin Transl Oncol. 2007 Oct;9(10):674-7. doi: 10.1007/s12094-007-0121-5.
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Spinal metastasis as the initial manifestation of a nonsecretory glucagonoma.脊柱转移作为非分泌性胰高血糖素瘤的首发表现。
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[Diagnostic imaging of glucagonoma and transcatheter arterial embolization in hepatic metastases--report of a case].
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Case of the season: glucagonoma syndrome.本季病例：胰高血糖素瘤综合征。
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引用本文的文献

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Application of Somatostatin, Chemotherapy Combined with TAE in Heterogeneous Glucagonoma Presented with Necrolytic Migratory Erythema.生长抑素、化疗联合肝动脉化疗栓塞术在以坏死性游走性红斑为表现的异质性胰高血糖素瘤中的应用
Onco Targets Ther. 2019 Dec 20;12:11339-11344. doi: 10.2147/OTT.S237634. eCollection 2019.
2
Causes of death and prognostic factors in multiple endocrine neoplasia type 1: a prospective study: comparison of 106 MEN1/Zollinger-Ellison syndrome patients with 1613 literature MEN1 patients with or without pancreatic endocrine tumors.1型多发性内分泌腺瘤病的死亡原因及预后因素：一项前瞻性研究：106例MEN1/卓艾综合征患者与1613例有或无胰腺内分泌肿瘤的文献报道的MEN1患者的比较
Medicine (Baltimore). 2013 May;92(3):135-181. doi: 10.1097/MD.0b013e3182954af1.

本文引用的文献

1
Endocrine tumours of the pancreas.胰腺内分泌肿瘤
Best Pract Res Clin Gastroenterol. 2005 Oct;19(5):753-81. doi: 10.1016/j.bpg.2005.06.002.
2
Guidelines for the management of gastroenteropancreatic neuroendocrine (including carcinoid) tumours.胃肠胰神经内分泌（包括类癌）肿瘤管理指南
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Prevalence, characteristics and prognosis of MEN 1-associated glucagonomas, VIPomas, and somatostatinomas: study from the GTE (Groupe des Tumeurs Endocrines) registry.
多发性内分泌腺瘤1型相关的胰高血糖素瘤、血管活性肠肽瘤和生长抑素瘤的患病率、特征及预后：来自内分泌肿瘤研究组（GTE）登记处的研究
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The diagnosis and medical management of advanced neuroendocrine tumors.晚期神经内分泌肿瘤的诊断与药物治疗
Endocr Rev. 2004 Jun;25(3):458-511. doi: 10.1210/er.2003-0014.
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Concurrent resections of pancreatic islet cell cancers with synchronous hepatic metastases: outcomes of an aggressive approach.胰腺胰岛细胞癌合并同步肝转移的同期切除术：积极治疗方法的结果
Surgery. 2002 Dec;132(6):976-82; discussion 982-3. doi: 10.1067/msy.2002.128615.
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The surgical management of pancreatic neuroendocrine tumors.胰腺神经内分泌肿瘤的外科治疗
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The glucagonoma syndrome: a review of its features and discussion of new perspectives.
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Pancreatic endocrine tumors.胰腺内分泌肿瘤
Curr Opin Oncol. 2001 Jan;13(1):52-6. doi: 10.1097/00001622-200101000-00010.
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Surgical strategy for large or malignant endocrine pancreatic tumors.大型或恶性胰腺内分泌肿瘤的手术策略
World J Surg. 2000 Nov;24(11):1353-60. doi: 10.1007/s002680010224.
10
Carcinoid and pancreatic endocrine tumors: recent advances in molecular pathogenesis, localization, and treatment.类癌和胰腺内分泌肿瘤：分子发病机制、定位及治疗的最新进展
Curr Opin Oncol. 2000 Jul;12(4):368-77. doi: 10.1097/00001622-200007000-00015.