Eller Triin, Vasar Veiko, Shlik Jakov, Maron Eduard
Department of Psychiatry, University of Tartu, Estonia.
Prog Neuropsychopharmacol Biol Psychiatry. 2008 Feb 15;32(2):445-50. doi: 10.1016/j.pnpbp.2007.09.015. Epub 2007 Sep 26.
Alterations in the immune system may have importance for the pathophysiology of depression. Several studies have linked increased production of pro-inflammatory cytokines to depression and depressive symptoms. There is growing evidence that antidepressive treatment may influence the production of pro-and anti-inflammatory cytokines. In the present study we aimed to find associations between the levels of soluble interleukin-2 receptor (sIL-2R), interleukin-8 (IL-8) and tumor necrosis factor alpha (TNF-alpha) and the response to antidepressant treatment in patients with major depression. Our study group consisted of 100 patients (35 males and 65 females) who were treated with escitalopram 10-20 mg/day for 12 weeks. Responders and non-responders were identified according to Montgomery-Asberg's Depression Rating Scale (MADRS) scores. The levels of cytokines were measured at baseline and at 4th and 12th week of the treatment and compared to cytokine concentrations in healthy volunteers (n=45; 19 males and 26 females). Our data indicated that a higher level of TNF-alpha might predict a non-response to treatment with escitalopram and that changes in concentrations of sIL-2R during the treatment were different in responders and non-responders.
免疫系统的改变可能对抑郁症的病理生理学具有重要意义。多项研究已将促炎细胞因子产生的增加与抑郁症及抑郁症状联系起来。越来越多的证据表明，抗抑郁治疗可能会影响促炎和抗炎细胞因子的产生。在本研究中，我们旨在寻找重度抑郁症患者中可溶性白细胞介素-2受体（sIL-2R）、白细胞介素-8（IL-8）和肿瘤坏死因子α（TNF-α）水平与抗抑郁治疗反应之间的关联。我们的研究组由100名患者（35名男性和65名女性）组成，他们接受了每天10 - 20毫克艾司西酞普兰的治疗，为期12周。根据蒙哥马利-阿斯伯格抑郁评定量表（MADRS）评分确定反应者和无反应者。在治疗的基线、第4周和第12周测量细胞因子水平，并与健康志愿者（n = 45；19名男性和26名女性）的细胞因子浓度进行比较。我们的数据表明，较高水平的TNF-α可能预示对艾司西酞普兰治疗无反应，并且治疗期间sIL-2R浓度的变化在反应者和无反应者中有所不同。
