Shang Xue-Jun, Wu Yi, Huang Yu-Feng
Department of Andrology, School of Clinical Medicine, Nanjing University Medical College, Nanjing General Hospital of Nanjing Command, Nanjing, Jiangsu 210002, China.
Zhonghua Nan Ke Xue. 2007 Oct;13(10):936-9.
Metallothioneins (MTs) are a group of intracellular proteins of low molecular weight and rich cysteine, encoded by a family of genes containing at least 10 functional isoforms in human. MTs widely exist in the male reproductive system and are involved in many pathophysiological processes such as metal ion homeostasis and detoxification, protection against oxidative damage, cell proliferation and apoptosis, chemoresistance and radiotherapy resistance. This review describes the location and effects of MTs in the male reproductive system.
金属硫蛋白（MTs）是一类低分子量且富含半胱氨酸的细胞内蛋白质，由人类中一个包含至少10种功能亚型的基因家族编码。MTs广泛存在于男性生殖系统中，并参与许多病理生理过程，如金属离子稳态与解毒、抗氧化损伤保护、细胞增殖与凋亡、化疗耐药和放疗抵抗。本文综述了MTs在男性生殖系统中的定位及作用。
