Sethy P G S, Bulliyya G, Mallick G, Swain B K, Kar S K
Regional Medical Research Centre, Indian Council of Medical Research, Bhubaneswar, India.
Indian J Pediatr. 2007 Oct;74(10):917-21. doi: 10.1007/s12098-007-0169-9.
The present study aimed at assessing the population prevalence of goiter and iodine deficiency in school children of 6-12 yr living in urban slums of Bhubaneswer, the capital city of Orissa.
A cross-sectional study was performed using the 30-cluster sampling methodology and surveillance methods for iodine deficiency as recommended by WHO/ICCIDD/UNICEF. The total goitre rate (n=1248), urinary iodine concentration (UIC) (n=411) and iodine content of edible salt (n=368) were measured.
The goitre prevalence was 23.6% (grade 1=18.9%, grade 2=4.7%) with no significant gender variation. Goitre prevalence was significantly higher in children of 10-12 yr (P=0.012) and scheduled caste and tribe (P=0.003). Median urinary iodine concentration was 50.0 microg/l with 85.7% of children having values less than 100 microg/l, indicating as biochemical iodine deficiency. Median UIC was inversely in association with gradations of goitre. Children of 10-12 yr and scheduled caste/tribe communities had significantly higher median UIC (P=0.001) than their counterpart peers. About 51% of children were consuming salt having stipulated iodine content of 15 ppm.
The study indicates moderate iodine deficiency in the population, despite a mandatory salt iodization programme in Orissa that has been in force since 1989. There is a need to improve the situation through enforcing monitoring of salt iodization to ensure quality and increasing the level of awareness about the iodized salt for sustainable prevention and control of iodine deficiency.
本研究旨在评估居住在奥里萨邦首府布巴内斯瓦尔城市贫民窟的6至12岁学童甲状腺肿和碘缺乏的人群患病率。
采用世界卫生组织/国际控制碘缺乏病理事会/联合国儿童基金会推荐的30群组抽样方法和碘缺乏监测方法进行横断面研究。测量了总甲状腺肿率(n = 1248)、尿碘浓度(UIC)(n = 411)和食用盐碘含量(n = 368)。
甲状腺肿患病率为23.6%(1级= 18.9%,2级= 4.7%),无明显性别差异。10至12岁儿童以及在册种姓和部落儿童的甲状腺肿患病率显著更高(P = 0.012和P = 0.003)。尿碘浓度中位数为50.0微克/升,85.7%的儿童值低于100微克/升,表明存在生化性碘缺乏。UIC中位数与甲状腺肿分级呈负相关。10至12岁儿童以及在册种姓/部落社区儿童的UIC中位数显著高于同龄儿童(P = 0.001)。约51%的儿童食用的盐碘含量规定为15 ppm。
该研究表明,尽管奥里萨邦自1989年以来实施了强制性食盐碘化计划,但该人群仍存在中度碘缺乏。需要通过加强食盐碘化监测以确保质量以及提高对碘盐的认识水平来改善这种情况,以实现碘缺乏病的可持续预防和控制。