Grossin Nicolas, Wautier Jean-Luc
Laboratoire de Biologie Vasculaire et Cellulaire, Institut National Transfusion Sanguine, Paris.
J Soc Biol. 2007;201(2):175-84. doi: 10.1051/jbio:2007022.
Advanced glycation end-products (AGE) are a group of heterogeneous molecules found in higher levels during diabetes, end stage renal failure and aging. Vascular alteration is correlated with their accumulation as during retinopathy or glomerulosclerosis. Glycation of extracellular matrix proteins is associated with diabetic angiopathy. AGE stimulate endothelial cell via the interaction with the receptor RAGE, leading to an inflammatory state with increased adhesion molecule expression, chemoattractant factor and tissue factor production. RAGE activation by AGE triggers reactive oxygen species production by NADPH oxydase. Agents that inhibit AGE formation, stimulate their degradation or neutralize their binding to RAGE represent new approaches to limit the deleterious activities of AGE.
晚期糖基化终末产物（AGE）是一组异质性分子，在糖尿病、终末期肾衰竭和衰老过程中含量较高。血管改变与它们的积累相关，如在视网膜病变或肾小球硬化过程中。细胞外基质蛋白的糖基化与糖尿病性血管病变有关。AGE通过与受体RAGE相互作用刺激内皮细胞，导致炎症状态，增加黏附分子表达、趋化因子和组织因子生成。AGE激活RAGE会触发NADPH氧化酶产生活性氧。抑制AGE形成、促进其降解或中和其与RAGE结合的药物是限制AGE有害活性的新方法。
