Zito M, Abate G, Cervone C, Squassante L, Calabrese G
Istituto di Geriatria e Gerontologia, Università G. D'Annunzio, Chieti, Italy.
J Hypertens Suppl. 1991 Dec;9(3):S79-83.
Recent multicenter trials have demonstrated that, in hypertensive elderly people, blood pressure control can significantly decrease the rate of cardiovascular and cerebrovascular events. Twenty-four-hour ambulatory blood pressure monitoring has proved to be superior to isolated sphygmomanometer blood pressure readings in the diagnostic evaluation of hypertension and in assessing the blood pressure response to treatment. We used 24-h ambulatory monitoring in a small, double-blind, randomly-allocated, placebo-controlled, parallel-group study of antihypertensive treatment with lacidipine given once a day at 2 or 4 mg. In our elderly subjects, the lacidipine treatment provided adequate blood pressure control both by day and by night with no effect on the heart rate profile. Furthermore, after drug therapy, we found a significant reduction in systolic blood pressure variability (standard deviation). This study shows that lacidipine can provide adequate control of arterial hypertension in the elderly.
近期的多中心试验表明，在老年高血压患者中，控制血压可显著降低心脑血管事件的发生率。24小时动态血压监测已被证明在高血压的诊断评估以及评估血压对治疗的反应方面优于单次血压计测量读数。我们在一项小型、双盲、随机分配、安慰剂对照、平行组研究中使用24小时动态血压监测，该研究采用每日一次给予2毫克或4毫克拉西地平进行抗高血压治疗。在我们的老年受试者中，拉西地平治疗在白天和夜间均能实现充分的血压控制，且对心率无影响。此外，药物治疗后，我们发现收缩压变异性（标准差）显著降低。这项研究表明，拉西地平能够为老年患者的动脉高血压提供充分控制。
