Stuhne-Sekalec L, Stanacev N Z
Department of Clinical Biochemistry, Banting Institute, Faculty of Medicine, University of Toronto, Ontario, Canada.
J Microencapsul. 1991 Oct-Dec;8(4):441-6. doi: 10.3109/02652049109021867.
Liposomes prepared from 1,2-dimyristoyl-sn-3-phosphatidylglycerol (DMPG) and 1,2-dimyristoyl-sn-3-phosphatidylcholine (DMPC) containing cyclosporin A (CsA) were reviewed in respect of the amount and localization of associated CsA. It was found that DMPG liposomes are capable of binding a much higher amount of CsA than those prepared from DMPC. Furthermore, while CsA associated with DMPG was embedded within the hydrophobic region of phospholipids, CsA associated with DMPC was excluded from the hydrophobic region and was entrapped in the hydrophilic region of these liposomes.
对由1,2-二肉豆蔻酰-sn-3-磷脂酰甘油（DMPG）和1,2-二肉豆蔻酰-sn-3-磷脂酰胆碱（DMPC）制备的含有环孢素A（CsA）的脂质体，就相关CsA的量和定位进行了综述。结果发现，DMPG脂质体比由DMPC制备的脂质体能够结合多得多的CsA。此外，与DMPG相关的CsA嵌入磷脂的疏水区域内，而与DMPC相关的CsA被排除在疏水区域之外，并被困在这些脂质体的亲水区域中。
